Differentiation of sensorimotor neuronal structures responsible for induction of motor evoked potentials, attenuation in detection of somatosensory stimuli, and induction of sensation of movement by mapping of optimal current directions

Electroencephalography and Clinical Neurophysiology
Alvaro Pascual-LeoneMark Hallett

Abstract

Transcranial magnetic stimulation (TMS) of the sensorimotor cortex can evoke motor evoked potentials (MEPs), attenuation in detection of somatosensory stimuli (ADSS), and sensation of movement (SOM) referred to the same body part. In this study we tried to differentiate the substrates responsible for these effects. In 6 normal volunteers, TMS was applied with a nearly monopolar Dantec stimulator and a butterfly coil. Optimal scalp location and current direction were determined for induction of MEPs in abductor pollicis brevis (APB), first dorsal interosseous (FDI), and adductor digiti minimi (ADM); SOM in digits 2 and 5 in an ischemically paralyzed hand; and ADSS applied to digits 2 and 5. All 3 muscles' MEPs and SOM and ADSS in both digits were optimally activated from a single scalp position. In all subjects, optimal current directions for MEPs pointed anteriorly; those for ADSS and SOM pointed posteriorly. Optimal current directions showed the same progression in all subjects for MEPs (ADM, FDI, and APB from antero-lateral to antero-medial), ADSS (digit 5 postero-medial, 2 postero-lateral), and SOM (digit 1 through 5 postero-lateral to postero-medial). We conclude that neuronal networks targeting corticospinal neurons respon...Continue Reading

References

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Jan 1, 1991·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·L G CohenM Hallett
Feb 1, 1994·Electroencephalography and Clinical Neurophysiology·A Pascual-LeoneM Hallett

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Citations

Sep 30, 2000·Brain Research. Brain Research Reviews·P M Rossini, F Pauri
May 1, 1998·Trends in Cognitive Sciences·R H Hamilton, A Pascual-Leone
Nov 29, 2005·Nature Neuroscience·Martin VossDaniel M Wolpert
Apr 29, 2005·Neuroreport·Patricia RomaiguèreJean-Pierre Roll
Aug 6, 2013·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Shahid BashirAlvaro Pascual-Leone
Jul 19, 2005·Annual Review of Neuroscience·Alvaro Pascual-LeoneLotfi B Merabet
Mar 20, 2004·Physical Medicine and Rehabilitation Clinics of North America·Paolo M Rossini, Gloria Dal Forno
Nov 4, 2017·Journal of Neurosurgery. Pediatrics·Anthony C WangJeffrey G Ojemann
Aug 5, 2008·Journal of Perinatal Medicine·Miriam Martínez-BiargeJosé Quero
Sep 17, 2017·Psychological Research·Claudia Carrara-Augustenborg, Benjamin G Schultz
Aug 19, 2017·Scientific Reports·Christian MerkelMircea Ariel Schoenfeld
Feb 27, 2021·Psychological Science·Tony Ro, Lua Koenig

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