Differentiation of Speech Delay and Global Developmental Delay in Children Using DTI Tractography-Based Connectome

AJNR. American Journal of Neuroradiology
J-W JeongHarry T Chugani

Abstract

Pure speech delay is a common developmental disorder which, according to some estimates, affects 5%-8% of the population. Speech delay may not only be an isolated condition but also can be part of a broader condition such as global developmental delay. The present study investigated whether diffusion tensor imaging tractography-based connectome can differentiate global developmental delay from speech delay in young children. Twelve children with pure speech delay (39.1 ± 20.9 months of age, 9 boys), 14 children with global developmental delay (39.3 ± 18.2 months of age, 12 boys), and 10 children with typical development (38.5 ± 20.5 months of age, 7 boys) underwent 3T DTI. For each subject, whole-brain connectome analysis was performed by using 116 cortical ROIs. The following network metrics were measured at individual regions: strength (number of the shortest paths), efficiency (measures of global and local integration), cluster coefficient (a measure of local aggregation), and betweeness (a measure of centrality). Compared with typical development, global and local efficiency were significantly reduced in both global developmental delay and speech delay (P < .0001). The nodal strength of the cognitive network is reduced in g...Continue Reading

References

Jan 1, 1992·Journal of Learning Disabilities·A S Bashir, A Scavuzzo
Apr 1, 1986·Archives of Neurology·S J HuberL E Clapp
Jun 1, 1983·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·S F CappaL A Vignolo
Jul 1, 1996·Developmental Medicine and Child Neurology·V BurdenI Goodyer
Jan 31, 2002·Nature Neuroscience·Daniëlle PosthumaDorret I Boomsma
Nov 6, 2004·NeuroImage·Sophia FrangouSteven C R Williams
Oct 6, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hilleke E Hulshoff PolRené S Kahn
Jul 28, 2007·The Behavioral and Brain Sciences·Rex E Jung, Richard J Haier
Dec 29, 2009·NeuroImage·Andrew ZaleskyEdward T Bullmore
Dec 3, 2010·Developmental Medicine and Child Neurology·Sarika U PetersElisabeth A Wilde
Apr 13, 2011·Pediatric Neurology·Benjamin J WilsonHarry T Chugani
Sep 25, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jeong-Won JeongHarry T Chugani
Jul 4, 2013·Brain : a Journal of Neurology·Marco CataniEmily Rogalski
Dec 11, 2013·Pediatric Research·Senthil SundaramHarry Chugani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine
Kouhei KamiyaKuni Ohtomo
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Elizabeth B Hutchinson, Daniel J Kelley
© 2022 Meta ULC. All rights reserved