PMID: 8470826Mar 1, 1993Paper

Differentiation of the mammalian retinal pigment epithelium in vitro: influence of presumptive retinal neuroepithelium and head mesenchyme

Anatomy and Embryology
E BuseA Leker

Abstract

The ancestor cells of the pigment epithelium of the mammalian eye are derived from the neuroepithelial cells of the neural plate. They are neurally determined in the process of neurulation but finally decide to follow the pigment cell lineage, whereas the adjacent tissue develops into the neuroretina and the optic stalk. This decision is most probably made in the developmental stage of eye cup formation. The pigment epithelium becomes restricted to the outer leaf of the eye cup and does not encroach on the adjacent neuroepithelial tissues of the internal leaf and the eye stalk. It is therefore supposed to be channelled by a locally confined determinant factor that has not yet been identified. In the present study, development of the mammalian eye and the neural versus pigment cell decision were investigated in mouse embryos. Three approaches were used to discover the source of the putative determinant involved in the process of neuroepithelial decision. First, eye primordia were cultured from stage 11 embryos (0 somites, early neural plate stage, embryonic day 7 1/2-8) to stage 16 embryos (34 somites, neural tube stage, ed 10); this is prior to pigment cell induction. The eye primordia were first cultured in head segments and t...Continue Reading

Citations

Jul 15, 2004·Anatomy and Embryology·Darka Bozanić, Mirna Saraga-Babić
Jan 27, 1998·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·M LudwigH Winking
Nov 22, 2017·Veterinary Pathology·Vanessa VrolykMarie-Odile Benoit-Biancamano
Mar 13, 2003·Development, Growth & Differentiation·Karine AngioiAdrien Duprez
Oct 10, 2003·European Journal of Cell Biology·Darka BozanićMirna Saraga-Babić

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