PMID: 4266014Mar 1, 1973

Differentiation of thymus-derived cells from precursors in mouse bone marrow

The Journal of Experimental Medicine
M O el-Arini, D Osoba

Abstract

An experimental model system was developed to study the differentiation of thymus-derived (T) cells from progenitors in bone marrow. In this system transplantation of bone marrow cells depleted of T cells gave rise to T cells in the spleens of irradiated recipients within 15 days of transplantation. Thus, normal bone marrow contains a class of cells that are progeniotrs of T cells (PT cells). PT cells are different from T cells since PT cells are incapable of responding to alloantigen, are theta resistant, and band in a lighter density region than do T cells. The density profile of PT cells is different from that of hematopoietic stem cells (CFU-S); PT cells band in a denser region of the gradient than do CFU-S.

References

Jan 1, 1980·Cellular Immunology·G KraalD Boden
Jan 1, 1990·Developmental and Comparative Immunology·J F SövényiR Kusuda
Jun 1, 1980·Immunopharmacology·L ZollingerM Paquette
Mar 27, 1975·The New England Journal of Medicine·P D Bertram
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R S Basch, G Goldstein
Nov 1, 1978·The Journal of Experimental Medicine·I GoldschneiderR J Morris
Jan 1, 1977·Immunological Reviews·H Cantor, E A Boyse
Jun 30, 1975·Annals of the New York Academy of Sciences·F Loor, G E Roelants
Dec 1, 1975·The Journal of Clinical Investigation·R P GaleD W Golde
Jul 1, 1978·Clinical Immunology and Immunopathology·J I Willis-CarrR J Wedgwood
Jan 1, 1988·European Journal of Immunology·P F Gallagher, J F Miller
Aug 15, 1980·Cellular Immunology·V Brankovan, C Rosse
Feb 1, 1984·Wilhelm Roux's Archives of Developmental Biology·Yehia Moustafa, Pierre Chibon

Citations

Jun 1, 1972·The Journal of Experimental Medicine·L LafleurR A Phillips
Oct 1, 1969·Journal of Cellular Physiology·R G WortonJ E Till
Apr 1, 1970·Journal of Cellular Physiology·P C NowellD B Wilson
Jul 1, 1966·Transplantation·A J DaviesP C Koller
Mar 10, 1956·Nature·C E FORDJ F LOUTIT
Dec 1, 1957·Journal of Cellular Physiology. Supplement·D W VAN BEKKUM, O VOS

Related Concepts

Centrifugation, Density Gradient
T-Lymphocyte
Colony-Forming Units, Hematopoietic
Spleen
Lymphocyte Culture Test, Mixed
Immune Sera
Effects of Radiation
Cell Differentiation Process
Hemolytic Complement
Transplantation, Homologous

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.