PMID: 6171575Nov 1, 1981Paper

Differentiation of troponin in cardiac and skeletal muscles in chicken embryos as studied by immunofluorescence microscopy

The Journal of Cell Biology
N Toyota, Y Shimada

Abstract

The differentiation of troponin (TN) in cardiac and skeletal muscles of chicken embryos was studied by indirect immunofluorescence microscopy. Serial sections of embryos were stained with antibodies specific to TN components (TN-T, -I, and -C) from adult chicken cardiac and skeletal muscles. Cardiac muscle began to be stained with antibodies raised against cardiac TN components in embryos after stage 10 (Hamburger and Hamilton numbering, 1951, J. Morphol. 88:49-92). It reacted also with antiskeletal TN-I from stage 10 to hatching. Skeletal muscle was stained with antibodies raised against skeletal TN components after stage 14. It also reacted with anticardiac TN-T and C from stage C from stage 14 to hatching. It is concluded that, during embryonic development, cardiac muscle synthesizes TN-T and C that possess cardiac-type antigenicity and TN-I that has antigenic determinants similar to those present in cardiac as well as in skeletal muscles. Embryonic skeletal muscle synthesizes TN-I that possesses antigenicity for skeletal muscle and TN-T and C which share the antigenicities for both cardiac and skeletal muscles. Thus, in the development of cardiac and skeletal muscles, a process occurs in which the fiber changes its genomic ...Continue Reading

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Citations

Apr 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M KomiyamaY Shimada
Aug 1, 1987·Developmental Biology·P M RongN M Le Douarin
May 1, 1988·Developmental Biology·C S Long, C P Ordahl
Apr 1, 1989·Developmental Biology·M NakamuraT Hirabayashi
Jan 1, 1996·Advances in Biophysics·Y ShimadaK Maruyama
Jan 1, 1988·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·S OhshimaT Obinata
Mar 1, 1994·Trends in Cardiovascular Medicine·G E Lyons
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Mar 10, 1994·The New England Journal of Medicine·J E AdamsA S Jaffe
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·L J SweeneyF J Manasek
Apr 1, 1986·The Journal of Cell Biology·L J Hayward, R J Schwartz
Feb 1, 1983·The Journal of Cell Biology·R H Gomer, E Lazarides
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Nov 7, 2001·Cardiology in Review·A S JaffeUNKNOWN American College of Cardiology
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Nov 9, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Luciano Babuin, Allan S Jaffe
Feb 5, 2014·Biochemistry. Biokhimii︠a︡·I A Katrukha
Dec 1, 2007·Biomarkers in Medicine·Vlad C Vasile, Allan S Jaffe

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