Differentiation of tuberculosis and metastatic cancer in the spine using dynamic contrast-enhanced MRI

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Ning LangHuishu Yuan

Abstract

To investigate the differences between imaging features of spinal tuberculosis (TB) and metastatic cancer measured by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). The presentation of TB on convention MRI may not show the typical TB signs, and they may be mis-diagnosed as malignant diseases. DCE-MRI may provide additional information to help making differential diagnosis. DCE-MRI was performed in 24 TB and 22 metastatic cancer patients. The DCE kinetic pattern was determined as "wash-out", "plateau" or "persistent enhancement". The characteristic DCE parameters were calculated from the signal intensity time course. The two-compartmental pharmacokinetic model was used to obtain K (trans), which is the parameter associated with the delivery of MR contrast agents into the lesion, and k ep, which is the parameter associated with the distribution and clearance of contrast agents from the lesion. Of the 24 TB, one case showed the wash-out kinetic pattern, 12 cases showed the plateau pattern, and 11 cases showed the persistent enhancement pattern. Of the 22 metastatic cancers, 12 cases showed wash-out, 7 cases showed plateau, and 3 cases showed persistent enhancement patterns. Compared to the metastatic cancer group,...Continue Reading

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Citations

Jan 7, 2016·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Robert C Mulholland
Aug 20, 2017·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Ahmed Abdel Khalek Abdel Razek, Germeen Albair Ashmalla
Feb 11, 2020·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Jiahui ZhangNing Lang
Dec 21, 2019·Neurology India·Sunitha Palasamudram KumaranSanjaya Viswamitra
Nov 23, 2019·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Jiahui ZhangNing Lang
Jul 28, 2016·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Xiao-Xi MengWei-Hua Dong
May 22, 2019·World Journal of Radiology·Mohamed R Nouh
Oct 30, 2021·Journal of Orthopaedic Surgery·Ajoy Prasad ShettyS Rajasekaran

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