Differentiation Potential of Human Chorion-Derived Mesenchymal Stem Cells into Motor Neuron-Like Cells in Two- and Three-Dimensional Culture Systems

Molecular Neurobiology
Faezeh FaghihiMohammad Taghi Joghataei

Abstract

Many people worldwide suffer from motor neuron-related disorders such as amyotrophic lateral sclerosis and spinal cord injuries. Recently, several attempts have been made to recruit stem cells to modulate disease progression in ALS and also regenerate spinal cord injuries. Chorion-derived mesenchymal stem cells (C-MSCs), used to be discarded as postpartum medically waste product, currently represent a class of cells with self renewal property and immunomodulatory capacity. These cells are able to differentiate into mesodermal and nonmesodermal lineages such as neural cells. On the other hand, gelatin, as a simply denatured collagen, is a suitable substrate for cell adhesion and differentiation. It has been shown that electrospinning of scaffolds into fibrous structure better resembles the physiological microenvironment in comparison with two-dimensional (2D) culture system. Since there is no report on potential of human chorion-derived MSCs to differentiate into motor neuron cells in two- and three-dimensional (3D) culture systems, we set out to determine the effect of retinoic acid (RA) and sonic hedgehog (Shh) on differentiation of human C-MSCs into motor neuron-like cells cultured on tissue culture plates (2D) and electrospu...Continue Reading

References

Apr 2, 1999·Science·M F PittengerD R Marshak
Aug 1, 2000·Experimental Neurology·J Sanchez-RamosP R Sanberg
Feb 14, 2002·Neurosurgery·Robert F HearyCristian Brotea
Aug 15, 2002·Cell·Hynek WichterleThomas M Jessell
Nov 5, 2002·Nature Reviews. Neuroscience·Malcolm Maden
Aug 22, 2003·Nature·Alison Abbott
Dec 8, 2004·Stem Cells·Pieternella S In 't AnkerHumphrey H H Kanhai
May 3, 2005·Journal of Biomedical Science·Elena KlyushnenkovaKevin R McIntosh
Jul 9, 2005·Journal of Biomaterials Science. Polymer Edition·Makoto Ozeki, Yasuhiko Tabata
Jan 13, 2006·Biochemical and Biophysical Research Communications·Xiaohong ZhangTsuneo A Takahashi
Jan 26, 2006·Experimental Neurology·Thomas BréjotDelphine Bohl
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Linda G Griffith, Melody A Swartz
Sep 28, 2007·The European Journal of Neuroscience·Eva HedlundOle Isacson
Sep 2, 2008·Biomaterials·Laleh Ghasemi-MobarakehSeeram Ramakrishna
Nov 14, 2008·Stem Cells and Development·Sarah BarlowKerry Atkinson
May 22, 2009·Biomacromolecules·Kristin SissonJohn F Rabolt
Jul 30, 2010·Cellular and Molecular Life Sciences : CMLS·M NizzardoS Corti
Sep 30, 2010·Journal of Biomaterials Applications·Eduardo Martín-LópezManuel Nieto-Sampedro
Jul 12, 2011·Tissue Engineering. Part a·Ebrahim ShahbaziHossein Baharvand
Nov 25, 2011·International Journal of Nanomedicine·Hadi HajialiHabibullah Peirovi
Mar 13, 2012·Clinical Implant Dentistry and Related Research·Kushel R MorjariaRichard M Palmer
Aug 10, 2012·Journal of Korean Medical Science·Bo Kyung KooJong-Hoon Kim
Jan 23, 2014·Tissue Engineering. Part C, Methods·Guihua JiangShaun M Kunisaki
Nov 6, 2014·Journal of Molecular Neuroscience : MN·Faezeh FaghihiMohammad Taghi Joghataei

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Citations

Jun 23, 2019·Developmental Neurobiology·Itai HennYossi Mandel
Feb 6, 2020·Cell Biology International·Narges MahmoodiVafa Rahimi-Movaghar
Oct 6, 2017·Biotechnology Journal·Sharanya SankarSeeram Ramakrishna
Apr 9, 2019·Stem Cells International·Agnese GugliandoloEmanuela Mazzon
Nov 24, 2016·Frontiers in Molecular Biosciences·Shripriya SinghChetan S Rajpurohit
Jun 21, 2017·Stem Cells International·Jing Qu, Huanxiang Zhang
Dec 24, 2018·Journal of Biomedical Science·Rossana BoniAndrew N Clarkson
Aug 29, 2020·Journal of Biomedical Materials Research. Part a·Nazanin GhaneSeeram Ramakrishna
Jul 23, 2020·APL Bioengineering·Ziqian LiuXiaoling Liu
Mar 6, 2021·Biomaterials Science·Himadri Shekhar RoyDeepa Ghosh
Jul 30, 2017·Journal of Chemical Neuroanatomy·Sepideh Alavi MoghaddamBabak Arjmand
May 18, 2021·Bioactive Materials·Kamil ElkhouryElmira Arab-Tehrany

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