Differing Developmental Trajectories in Heart Rate Responses to Speech Stimuli in Infants at High and Low Risk for Autism Spectrum Disorder

Journal of Autism and Developmental Disorders
Katherine L PerdueCharles A Nelson

Abstract

We investigated heart rate (HR) in infants at 3, 6, 9, and 12 months of age, at high (HRA) and low (LRC) familial risk for ASD, to identify potential endophenotypes of ASD risk related to attentional responses. HR was extracted from functional near-infrared spectroscopy recordings while infants listened to speech stimuli. Longitudinal analysis revealed that HRA infants and males generally had lower baseline HR than LRC infants and females. HRA infants showed decreased HR responses to early trials over development, while LRC infants showed increased responses. These findings suggest altered developmental trajectories in physiological responses to speech stimuli over the first year of life, with HRA infants showing less social orienting over time.

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Citations

Aug 21, 2018·Developmental Psychobiology·Kristie L Poole, Louis A Schmidt
Nov 6, 2018·Journal of Biomedical Optics·Naser Hakimi, Seyed Kamaledin Setarehdan
Feb 15, 2018·Journal of Neurodevelopmental Disorders·Bridgette L TonnsenJane E Roberts
Sep 1, 2019·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Frederick ShicKatarzyna Chawarska
Jul 21, 2020·Development and Psychopathology·Gabrielle M Tiede, Katherine M Walton
Nov 28, 2020·Developmental Cognitive Neuroscience·Laurie BayetCharles A Nelson
Feb 20, 2021·Pediatric Research·Kaitlin R BlackardKaren D Fairchild
Jun 3, 2021·International Journal of Molecular Sciences·Filipe Gonçalves CostaFrank Van Bel

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