Aug 13, 2010

Differing effect of modifiable cardiovascular risk factors on intima-media thickening and plaque formation at different sites of the arterial vasculature

Heart
Sanjay ChaubeyShah Ebrahim

Abstract

The effects of cardiovascular risk factors on the vascular anatomy at differing sites of the arterial vasculature have not been well described. The aim of this study was to compare the effect of cardiovascular risk factors on the intima media thickness (IMT) of the wall of the right and left common carotid artery (CCA) at their bifurcation and proximal from their bifurcation, and the effects on the presence of plaque at carotid and femoral arteries. Cross-sectional population-based study. Random samples of men (n=425) and women (n=367) aged 56-77 years were recruited from two general practices participating in the British Regional Heart Study. Ultrasound examination ascertained IMT and the presence of atheromatous plaque. A model for correlated outcomes was used to simultaneously model all risk factor on all measured vascular sites. All cardiovascular risk factors (HbA(1c), waist-to-hip ratio, hypertension, LDL and smoking) showed a larger association with IMT thickening at the wall of the CCA at its bifurcation than proximal to its bifurcation. The IMT was greater on the left wall of the CCA than on the right. The association between hypertension with the wall of the CCA depended on age. Smoking was the only risk factor that d...Continue Reading

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Mentioned in this Paper

Prevalence Studies
Intima
Tunica Intima
Plaque, Atherosclerotic
Blood Vessel
Common Carotid Artery
Anatomic Bifurcation
Dental Plaque
Cardiovascular Diseases
Arterial Fatty Streak

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