Differing intrinsic biological properties between forebrain and spinal oligodendroglial lineage cells

Journal of Neurochemistry
Makoto HoriuchiTakayuki Itoh

Abstract

Differentiation of oligodendroglial progenitor cells (OPCs) into myelinating oligodendrocytes is known to be regulated by the microenvironment where they differentiate. However, current research has not verified whether or not oligodendroglial lineage cells (OLCs) derived from different anatomical regions of the central nervous system (CNS) respond to microenvironmental cues in the same manner. Here, we isolated pure OPCs from rat neonatal forebrain (FB) and spinal cord (SC) and compared their phenotypes in the same in vitro conditions. We found that although FB and SC OLCs responded differently to the same external factors; they were distinct in proliferation response to mitogens, oligodendrocyte phenotype after differentiation, and cytotoxic responses to α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate-type glutamate receptor-mediated excitotoxicity at immature stages of differentiation in a cell-intrinsic manner. Moreover, transcriptome analysis identified genes differentially expressed between these OPC populations, including those encoding transcription factors (TFs), cell surface molecules, and signaling molecules. Particularly, FB and SC OPCs retained the expression of FB- or SC-specific TFs, such as Foxg1 and Hoxc8, res...Continue Reading

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Citations

Mar 21, 2019·Journal of Neuroscience Research·Yulius HermantoJun Takahashi
Oct 29, 2019·ELife·Matthew SwireCharles Ffrench-Constant
Jan 30, 2021·Current Opinion in Neurobiology·Greta Limoni, Mathieu Niquille

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