Abstract
Plasma concentrations of both atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are elevated in severe hypertension, acute myocardial infarction, and heart failure. In the current study of individuals with essential hypertension, we have documented the hemodynamic, hormonal, and endocrine effects of infusions of these two peptides given alone or in combination in equimolar doses calculated to induce increments in plasma peptides to concentrations (30 to 60 pmol/L) observed in these disease states. The metabolic clearance rate of ANP (4.56 +/- 0.62 L/min) was greater than that for BNP (3.4 +/- 0.23 L/min, P <.001). Infusions of each cardiac hormone impaired the clearance of coinfused peptide. All peptide infusions enhanced natriuresis (17% to 70% above preinfusion levels versus placebo, 6%; P <.001), lowered blood pressure (10 to 18 mm Hg fall in mean arterial pressure below placebo levels; P <.001), increased hematocrit, suppressed the renin-angiotensin-aldosterone system, and enhanced plasma norepinephrine concentrations. The natriuretic and blood pressure-lowering effects of BNP were twofold to threefold those of ANP. In contrast, ANP-induced increments in plasma and urinary second messenger (cGMP) levels w...Continue Reading
References
Apr 1, 1976·Australian and New Zealand Journal of Medicine·P J Dunn, E A Espiner
Oct 15, 1991·Biochemical and Biophysical Research Communications·M MukoyamaH Yasue
Oct 1, 1991·American Journal of Hypertension·A S Hollister, T Inagami
Apr 1, 1991·The Journal of Clinical Investigation·M MukoyamaH Yasue
Apr 1, 1990·The Journal of Clinical Endocrinology and Metabolism·A McGregorH Ikram
Jun 1, 1989·Hypertension·W M JanssenP E de Jong
Sep 1, 1989·Hypertension·A M RichardsT G Yandle
Jan 25, 1986·Lancet·G A SagnellaG A MacGregor
Mar 7, 1986·Science·J C BurnettG S Reeder
May 19, 1986·Life Sciences·T G YandleJ H Livesey
Jun 1, 1986·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·P WeidmannF C Reubi
Dec 1, 1987·Hypertension·P MontorsiA M Richards
Mar 3, 1988·Nature·T SudohH Matsuo
Mar 1, 1988·The Journal of Clinical Endocrinology and Metabolism·A M RichardsJ J Morton
Sep 1, 1985·Hypertension·A M RichardsM M Cullens
Feb 2, 1981·Life Sciences·D S GoldsteinH R Keiser
Jan 1, 1995·Clinical Science·R I CargillB J Lipworth
Jun 1, 1994·Clinical Science·B M CheungJ Brown
Apr 1, 1993·The Biochemical Journal·A J KennyJ Ingram
May 1, 1993·Lancet·J G MotwaniA D Struthers
Feb 1, 1993·Journal of Hypertension·A M RichardsC Frampton
Nov 1, 1996·The Journal of Clinical Endocrinology and Metabolism·P J HuntT G Yandle
Citations
Jul 16, 2008·European Journal of Clinical Pharmacology·Hironobu MinamiShinichiro Ueda
Feb 29, 2008·Pediatric Cardiology·Daniel HolmgrenHåkan Wåhlander
Dec 3, 2011·Current Hypertension Reports·Paul M McKieJohn C Burnett
Apr 1, 1997·The Annals of Thoracic Surgery·A El GamelA K Deiraniya
Nov 27, 1999·Life Sciences·Y J QinJ Tang
Jan 13, 1998·Journal of the American College of Cardiology·N NagayaK Kangawa
Dec 28, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·T AzizN Yonan
May 20, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yuki MorinagaKiyoshi Matsumura
May 29, 2002·Clinical Endocrinology·Eric A EspinerA Mark Richards
Feb 24, 1999·Journal of Cardiovascular Pharmacology·C J CharlesA M Richards
Sep 28, 2002·Journal of Cardiovascular Pharmacology·Pitt O LimThomas M MacDonald
Sep 26, 2003·Journal of Cardiovascular Pharmacology·Anton H van den MeirackerFrans Boomsma
Oct 4, 2005·The Journal of Clinical Investigation·Takahiro KatoMark A Sussman
Sep 30, 2005·Pediatric Research·Maureen HackMahboob Rahman
May 31, 2007·Neurological Research·Jian HaiMei-Xiu Ding
Aug 12, 2014·Regulatory Peptides·Song GuoMessoud Ashina
Sep 30, 2015·Peptides·Song GuoMessoud Ashina
Jun 1, 2007·European Journal of Pharmacology·Verónica SosaVerónica Guarner
Jul 21, 2009·European Journal of Clinical Investigation·N ShushakovaD Fliser
Mar 17, 2004·The American Journal of Cardiology·Keisuke KawaiMitsuhiro Yokoyama
Mar 20, 1998·American Heart Journal·M NakamuraK Hiramori
Sep 20, 2002·Neurological Research·Kazuhiko NakagawaMaki Yoshino
Sep 22, 2000·Pharmacotherapy·A J ChaK W Judge
Jul 14, 2005·Fundamental & Clinical Pharmacology·Alphons J H M HoubenPeter W de Leeuw
Oct 28, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Guido BoerrigterJohn C Burnett
Sep 7, 2017·Current Medicinal Chemistry·Evangelos OikonomouDimitris Tousoulis
Oct 30, 2007·Cellular & Molecular Biology Letters·Mariusz PiechotaJacek Rysz
Feb 18, 1999·The Journal of Clinical Endocrinology and Metabolism·J G LainchburyT G Yandle
Jul 25, 2019·International Journal of Molecular Sciences·Ryuji OkamotoMasaaki Ito
Jan 22, 1998·The American Journal of Physiology·B G BruneauA J de Bold