Differing molecular pathology of pancreatic adenocarcinoma in Egyptian and United States patients

International Journal of Cancer. Journal International Du Cancer
Amr S SolimanStanley R Hamilton

Abstract

Variations in genetic mutations in pancreatic carcinoma between different populations have not been studied extensively, especially in developing countries where pancreatic cancer is rare. We studied the molecular pathology of 44 pancreatic carcinomas from patients residing in a heavily polluted region in the Nile River delta and compared the findings with tumors from 44 United States (US) patients. We evaluated K-ras mutations in codon 12, p53 mutations in exons 5-8, and Gadd45a mutations in exons 1 and 4. Overall, rates of K-ras, p53 and Gadd45 mutations were not statistically different in tumors of patients from Egypt and the US (67.4 vs. 63.4%; 27.3 vs. 36.4% and 9.1 vs. 4.5%, respectively). However, there were distinct differences in the specific types of K-ras and p53 mutations between the 2 groups. In K-ras, G --> T transversion mutation was more frequent in the tumors from Egypt than from the US (58.6 vs. 26.9%), whereas G --> C transversion was detected in 26.9% of US tumors but none from Egypt (p = 0.003). We also found a trend toward differences in the p53 exons in which mutations occurred, with higher frequency of exon 5 mutation and lower frequency of exon 6 mutation in Egyptian tumors. Logistic regression showed t...Continue Reading

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Citations

Dec 17, 2008·Cancer Causes & Control : CCC·Marta Crous-BouUNKNOWN PANKRAS II Study Group
Feb 3, 2011·Hepatology International·Amr S SolimanKadry Ismail
Jun 15, 2007·Journal of Epidemiology and Community Health·Eva MoralesUNKNOWN PANKRAS II Study Group
Mar 19, 2008·Digestive Diseases and Sciences·Marta Crous-BouUNKNOWN PANKRAS II Study Group
Oct 28, 2006·Cancer Detection and Prevention·Amr S SolimanJames L Abbruzzese
Mar 28, 2009·Environmental and Molecular Mutagenesis·Marta Crous-BouUNKNOWN PANKRAS II Study Group
Aug 19, 2008·Environmental Research·Miquel PortaUNKNOWN PANKRAS II Study Group

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