Differing phagocytic capacities of accessory and main olfactory ensheathing cells and the implication for olfactory glia transplantation therapies

Molecular and Cellular Neurosciences
Lynnmaria NazarethJenny A K Ekberg

Abstract

The rodent olfactory systems comprise the main olfactory system for the detection of odours and the accessory olfactory system which detects pheromones. In both systems, olfactory axon fascicles are ensheathed by olfactory glia, termed olfactory ensheathing cells (OECs), which are crucial for the growth and maintenance of the olfactory nerve. The growth-promoting and phagocytic characteristics of OECs make them potential candidates for neural repair therapies such as transplantation to repair the injured spinal cord. However, transplanting mixed populations of glia with unknown properties may lead to variations in outcomes for neural repair. As the phagocytic capacity of the accessory OECs has not yet been determined, we compared the phagocytic capacity of accessory and main OECs in vivo and in vitro. In normal healthy animals, the accessory OECs accumulated considerably less axon debris than main OECs in vivo. Analysis of freshly dissected OECs showed that accessory OECs contained 20% less fluorescent axon debris than main OECs. However, when assayed in vitro with exogenous axon debris added to the culture, the accessory OECs phagocytosed almost 20% more debris than main OECs. After surgical removal of one olfactory bulb which...Continue Reading

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Citations

Nov 26, 2015·Neural Regeneration Research·Jenny A K Ekberg, James A St John
Dec 29, 2018·The Journal of Comparative Neurology·Lynn NazarethJenny A K Ekberg
Nov 15, 2019·Muscle & Nerve·Carrie A KubiakStephen W P Kemp
Oct 22, 2019·Cancer Cell International·Mariyam MurtazaJenny A K Ekberg
Feb 15, 2020·Journal of Neurotrauma·Aaron D GilmourJames A St John
Oct 16, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ding-Jun HaoHao Yang
Jul 22, 2018·Neural Regeneration Research·Kate BeecherFatemeh Chehrehasa
Jan 31, 2021·Tissue Engineering and Regenerative Medicine·Jong-Yoon LeeSang-Uk Lee
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Lynn NazarethJenny Ekberg

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