Differing psychological vulnerabilities among behaviourally and perinatally HIV infected adolescents in South Africa - implications for targeted health service provision

AIDS Care
Lorraine SherrE He

Abstract

HIV infections are growing the fastest amongst adolescents, especially in sub Saharan Africa. On reaching adolescence, perinatally-infected youth may have different needs to those who acquired infection behaviourally. Yet both have sub-optimal adherence with implications for their own health as well as onward transmission. This study uses the world's largest community-based study of HIV-positive adolescents from the Eastern Cape, South Africa. Clinic records at N = 53 district health facilities generated a log of all ART-initiated adolescents who were then interviewed in the community: N = 1058 (90%) were tracked and participated. Ethical approval, informed consent and data collector training preceded data gathering. Inventories comprised validated measures of mental health (depression, anxiety, suicidality and internalised stigma), substance use, ART adherence, and clinic attendance. Analyses were conducted using SPSS25 and STATA15. Perinatally-infected adolescents (n = 792, 77.3%) were significantly more likely to be ART adherent (OR = 1.54 95%CI: 1.14-2.07 p = 0.005), retained in healthcare (OR = 1.59 95%CI1.18-2.14 p = 0.002), and treated well by clinic staff (OR = 2.12 95%CI1.59-3.07 p ≤ 0.001). Behaviourally-infected adol...Continue Reading

References

Jun 1, 1978·Journal of Abnormal Child Psychology·C R Reynolds, B O Richmond
Nov 1, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Don OperarioHelen Rees
Dec 23, 2006·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Kathryn WrightMaureen Frey
Aug 23, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Lucie CluverFranziska Meinck
Aug 21, 2012·Journal of the International AIDS Society·Janet SeeleyAlan Whiteside
Oct 26, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert F MillerRashida A Ferrand
Jan 11, 2014·The Lancet Infectious Diseases·Elizabeth D LowenthalRashida A Ferrand
Mar 29, 2014·Current HIV/AIDS Reports·Wim Delva, Quarraisha Abdool Karim
Oct 14, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Nigel C RollinsUNKNOWN INSPIRE Team
Apr 12, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Quarraisha Abdool KarimDeborah Birx
May 23, 2017·Journal of the International AIDS Society·Amy L SlogroveMary-Ann Davies
May 23, 2017·Journal of the International AIDS Society·Désiré Lucien DahourouValériane Leroy
May 23, 2017·Journal of the International AIDS Society·Phung Khanh LamCaroline Foster
May 23, 2017·Journal of the International AIDS Society·Daniella MarkLuann Hatane
Mar 13, 2018·Current Opinion in HIV and AIDS·Audrey PettiforLinda-Gail Bekker

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Citations

Jul 18, 2018·AIDS Care·Sarah SkeenLorraine Sherr
Jul 25, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Roxanna HaghighatAnurita Bains
Aug 9, 2019·International Journal of Adolescent Medicine and Health·Cara HainesNina Higson-Sweeney
Mar 28, 2020·International Journal of Behavioral Medicine·Derrick SsewanyanaAmina Abubakar
Aug 15, 2020·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Sarah BernaysSara Paparini
Oct 29, 2021·Journal of the International AIDS Society·Siyanai ZhouElona Toska

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