PMID: 8603033Jan 1, 1996Paper

Differing shapes of 1 alpha,25-dihydroxyvitamin D3 function as ligands for the D-binding protein, nuclear receptor and membrane receptor: a status report

The Journal of Steroid Biochemistry and Molecular Biology
A W NormanW H Okamura

Abstract

1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3] is the principal mediator of a wide array of biological responses through the far reaching network of the vitamin D endocine system (VDE). The steroid hormone 1 alpha,25(OH)2D3 is delivered to the various target organs of the VDE via a specific plasma transport protein, the vitamin D binding protein (DBP). Also 1 alpha,25(OH)2D3 is known to initiate biological responses through a nuclear receptor, the nVDR (50 kDa) which regulates selected gene transcription and, in addition in some target tissues, through a second receptor located in the cell membrane, the mVDR (approximately 60 kDa), which is linked to protein kinase C and/or voltage-gated Ca2+ channels so as to generate biological responses very rapidly. 1 alpha,25(OH)2D3 as a ligand is unusually conformationally flexible due to the eight carbon side chain, the seco B-ring which permits rotation about the 6-7 single carbon bond, and the A-ring which undergoes chair-chair conformational interconversion characteristic of cyclohexane rings. This paper reviews the evidence that different shapes of the 1 alpha,25(OH)2D3 satisfy the optimal requirements of the ligand binding domains of the DBP, nVDR and mVDR. The presence of a rel...Continue Reading

References

Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·A W NormanM C Farach-Carson
Apr 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L X ZhouA W Norman
May 1, 1992·Journal of Cellular Biochemistry·W H OkamuraM M Midland
Dec 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D T BaranJ Lian
Jan 15, 1990·Biochemical and Biophysical Research Communications·A R de BolandA W Norman
May 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D T BaranM F Holick
Apr 13, 1989·The New England Journal of Medicine·H ReichelA W Norman
Dec 1, 1988·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P P Minghetti, A W Norman
Nov 1, 1994·Nutrition Reviews·S S Hannah, A W Norman
Mar 24, 1995·The Journal of Biological Chemistry·S J SlaterC D Stubbs
Aug 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J E BishopA W Norman

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Citations

May 29, 2002·Experimental Hematology·Dora Ben AlonIlana Nathan
Nov 17, 2001·Bioorganic & Medicinal Chemistry·T A BonaseraB Långström
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·A RevelliJ Tesarik
Sep 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mohand MesbahAriane Berdal
Sep 24, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sandro Mazzaferro, Marzia Pasquali
May 14, 2011·Life Sciences·Leila ZanattaFátima Regina Mena Barreto Silva
Jul 4, 2006·Journal of Molecular and Cellular Cardiology·John J GreenMargaret V Westfall
Jun 26, 1999·The Journal of Biological Chemistry·A Racz, J Barsony
Nov 1, 2008·Expert Review of Clinical Pharmacology·William M Brown
Jun 7, 2002·The Journal of Clinical Endocrinology and Metabolism·Claus Højbjerg GravholtJens Sandahl Christiansen
Jul 5, 2003·Physiological Reviews·Ralf M LoselMartin Wehling
Aug 21, 2020·Current Topics in Medicinal Chemistry·Seck InsaSeck Matar

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