Difficulties and limitations in conducting translational research in thoracic oncology. A practical example

Revue des maladies respiratoires
A-P MeertThierry Berghmans

Abstract

In a first study, we identified signatures of 3 mRNAs (semaphorin 3D [SEMA3D], cytokeratin 16 [KRT16] and UL16 binding protein 2 [ULBP2]) associated to response to a cisplatin-vinorelbin chemotherapy and to survival of advanced non-small cell lung cancers (NSCLC). The aim of this study was to develop immunohistochemistry tests for KRT16, ULBP2 and SEMA3D and to test proteins expression for prediction of response and survival in biopsies of the same patients. We were not able to reproduce by the protein expression study the signature predicting response to chemotherapy in advanced NSCLC. We highlight the difficulties of translational research in thoracic oncology emphasizing the complexity in obtaining adequate tissue samples and the difficulties in conduction and transposing in routine practice high throughput technique for transcriptomic analyses.

References

Jul 16, 2002·Nature Medicine·David G BeerSamir Hanash
Feb 17, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Anne-Pascale MeertJean-Paul Sculier
Jul 3, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Manuel CoboRafael Rosell
Dec 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Suzanne K LauMing-Sound Tsao
Jul 22, 2008·Nature Medicine·UNKNOWN Director's Challenge Consortium for the Molecular Classification of Lung AdenocarcinomaDavid G Beer
Jan 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paul RoepmanNico van Zandwijk
Feb 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Paul C BoutrosIgor Jurisica
Aug 27, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chang-Qi ZhuIgor Jurisica
Sep 7, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·T BerghmansUNKNOWN European Lung Cancer Working Party
Sep 13, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Christos ChouaidAlain Vergnenegre
Feb 24, 2015·Revue des maladies respiratoires·C Leduc, B Besse

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