Difficulties in the diagnosis of four repeats (4R) tauopathic parkinsonian syndromes

Neurologia i neurochirurgia polska
Piotr AlsterAndrzej Friedman

Abstract

Corticobasal Degeneration Degeneration (CBD) and Progressive Supranuclear Palsy (PSP) are types of four repeats (4R) tauopathies, which are associated to parkinsonian syndromes. The aim of the work is to analyze cases of patients of the Department of Neurology, overlapping of syndromes related to both pathologies and to show that most likely CBS and PSP are not lineary related to their commonly associated syndromes i.e. adequately corticobasal syndromes and progressive supranuclear palsy syndromes. In the context of each patient factors in favor of most likely CBS, PSP or both diseases are discussed and analyzed using contemporary criteria. This work discusses multidimensional aspect of the examination of five patient aged 64 to 83 - 4 females and 1 male with 4R tauopathies and difficulties in distinguishing both diseases. The duration of the disease varied from 1 to 5 years. Each patient after neurological examination was assessed using magnetic resonance imaging (MRI) and psychological test. Examination of all patients was extended using single photon emission computer tomography (SPECT) to reveal the usefulness of this tool in differentiation of diseases was done. The outcome of this examination was verified with prior clini...Continue Reading

References

Nov 15, 2002·Journal of Neuropathology and Experimental Neurology·D W DicksonUNKNOWN Office of Rare Diseases of the National Institutes of Health
Apr 5, 2007·Brain : a Journal of Neurology·Lawrence I Golbe, Pamela A Ohman-Strickland
Nov 19, 2008·Parkinsonism & Related Disorders·Pettarusp M Wadia, Anthony E Lang
Nov 26, 2010·Neurology·J L WhitwellK A Josephs
Jul 2, 2011·Journal of Molecular Neuroscience : MN·Dennis W DicksonKeith A Josephs
Oct 22, 2011·Expert Review of Neurotherapeutics·Anhar HassanKeith A Josephs
Jan 30, 2013·Neurology·Melissa J ArmstrongWilliam J Weiner
Feb 15, 2013·Acta Neurologica Scandinavica·R M LiscicD Berg
Feb 26, 2013·Neuropathology and Applied Neurobiology·Helen LingT Revesz
Jun 12, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J L WhitwellK A Josephs
Oct 5, 2013·Continuum : Lifelong Learning in Neurology·David R Williams, Irene Litvan
Apr 24, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·James R BurrellJames B Rowe
Aug 16, 2014·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Mari Yoshida
Oct 4, 2014·Neurology. Clinical Practice·Lama M ChahineRachel G Gross
Sep 29, 2015·Journal of Movement Disorders·Sun Young ImYun Joong Kim
Oct 13, 2015·Parkinsonism & Related Disorders·M GrunhoI Litvan
Dec 15, 2015·Neurologia i neurochirurgia polska·Magda DąbrowskaJarosław Sławek
Feb 2, 2016·Journal of Movement Disorders·Helen Ling
May 28, 2016·The Cerebellum·Martin PaucarPer Svenningsson
Oct 16, 2016·Neurology·Shubir DuttUNKNOWN AL-108-231 investigators
Nov 16, 2016·Acta Neuropathologica Communications·Carolin KurzGünter Ulrich Höglinger
May 4, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Günter U HöglingerUNKNOWN Movement Disorder Society-endorsed PSP Study Group

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