Diffuse Alveolar Hemorrhage Caused by Warfarin after Rifampicin Discontinuation

Case Reports in Medicine
Takashige KiyotaEishi Miyazaki

Abstract

An 83-year-old man under warfarin therapy presented for assessment of prolonged prothrombin time and cough. High-resolution computed tomography findings of the chest showed diffuse alveolar hemorrhage. His international normalized ratio (INR) was 11.89. He had been treated with rifampicin for a persistent infection, but this had been discontinued about two months before admission. Rifampicin suppresses the anticoagulant activity of warfarin, which can lead to a need for increased doses of warfarin to achieve and maintain a therapeutic INR. More frequent INR monitoring is needed even after discontinuing rifampicin.

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Citations

May 19, 2020·British Journal of Haematology·Yong LiXiaoxiang Yan
Aug 4, 2019·BMJ Case Reports·Kamal Kant SahuVenkateswara Davuluri
Feb 6, 2021·Pharmacogenomics and Personalized Medicine·Muhammad SalemHazem Elewa
Nov 7, 2019·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Solmaz BorjianMohammad Amin Borjian

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