PMID: 43014Jan 1, 1979

Diffuse glomerulosclerosis--a dysfunction of the mesangium? A morphometric study of the rat's kidney

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
W Romen, R Morath


The phagocytic capacity of the glomerular mesangial cells in 42 rats was inhibited by the prolonged injection of PVA. Morphometric evaluation of electron microscopic sections showed that this treatment leads to an accelerated thickening of the lamina densa of the glomerular basement membrane and of the mesangial matrix (early glomerulosclerosis). This suggests that a disturbance of lysosomal degradation can lead to glomerulosclerosis, and that the possibility of mesangial dysfunction should always be considered as a possible factor in the pathogenesis of all types of diffuse glomerulosclerosis.


Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·A NaramotoH Shigematsu
Jul 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D C Leegwater, C F Kuper


Sep 1, 1978·The Tohoku Journal of Experimental Medicine·S Yagihashi
Jan 1, 1976·Experimental Gerontology·N A McNelly, J E Dittmer
Jan 1, 1969·International Review of Cytology·E R Weibel
Mar 15, 1967·Klinische Wochenschrift·O Fresen, V Sadony
Jan 1, 1957·The American Journal of Anatomy·W ANDREW, D PRUETT

Related Concepts

Pathogenic Aspects
Diffuse Mesangial Sclerosis (Disorder)
Diabetic Nephropathy
Lamina Densa
Ischemic Glomerulopathy
Electron-dense Layer of Basal Lamina of Connective Tissue
Glomerulosclerosis (Disorder)
Nodular Glomerulosclerosis
Basal Lamina

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