PMID: 11913571Mar 27, 2002Paper

Diffuse magnetic resonance imaging white-matter changes in a 15-year-old boy with mitochondrial encephalomyopathy

Journal of Child Neurology
Arie WeinstockLucy Balos

Abstract

We report a 15-year-old boy who presented with recurrent headaches associated with numbness, confusion, and speech difficulty. Brain magnetic resonance imaging (MRI) revealed diffuse bilateral white-matter hyperintensity on fluid-attenuated inversion-recovery and T2-weighted images in the internal capsule, periventricular and subcortical white matter, base of the pons, and middle cerebellar peduncles. Lesions were isointense on T1-weighted images and nonenhancing. Muscle biopsy showed changes consistent with a mitochondrial myopathy. Mitochondrial respiratory chain enzyme activity analysis revealed a significant reduction in complex II activity. Genetic testing was negative. We conclude that mitochondrial encephalomyopathy may present with unusual diffuse supratentorial and infratentorial white-matter changes on MRI.

References

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Citations

May 27, 2009·Der Nervenarzt·J Finsterer
Dec 5, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrea L Gropman
Mar 24, 2011·Epilepsia·Shan TangKarine Lascelles
Sep 1, 2006·Acta Neurologica Scandinavica·J Finsterer
Feb 7, 2012·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Josef Finsterer, Sinda Zarrouk Mahjoub
Sep 8, 2010·Developmental Disabilities Research Reviews·Seth D FriedmanRussell P Saneto
Jul 7, 2018·The Neuroradiology Journal·Josef Finsterer, Sinda Zarrouk-Mahjoub
Nov 10, 2005·American Journal of Medical Genetics. Part a·Maria PiccioneGiovanni Corsello
May 28, 2005·Metabolic Brain Disease·Josef FinstererHelmut Rumpold
Apr 22, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Josef Finsterer

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