Diffuse narrowing of coronary arteries in diabetic patients: the earliest phase of coronary artery disease

Cardiology
M MosseriM S Gotsman

Abstract

Coronary arteries in diabetic patients appear to be narrower than in normal subjects, but this has not been examined systematically. To investigate this hypothesis we reviewed the data of 711 consecutive patients with angiographically 'normal coronary arteries'. Excluded were patients with valvular, myocardial or pericardial disease, and patients with hypertension or hyperlipidemia. Thirteen diabetic patients (10 men) and 22 nondiabetic persons (8 men) constituted the study and control groups, respectively. The diameters of the coronary arteries and their branches were measured and adjusted for body surface area. The sum of the proximal left anterior descending (LAD), circumflex and right coronary arteries (RCA) was calculated and defined as total coronary diameter (TCD). The sum of the distal LAD, first diagonal, first marginal and distal RCA was calculated and defined as total distal coronary diameter (dTCD). The clinical data of both groups were comparable. Adjusted TCD for body surface area was 5.4 +/- 1.1 and 6.5 +/- 1.1 mm/m2 (p < 0.05) in diabetics and nondiabetics, respectively, and adjusted dTCD was 4.9 +/- 1.2 and 6.1 +/- 1.2 mm/m2 (p = 0.01) in diabetics and normal subjects, respectively. Specific arteries and branch...Continue Reading

Citations

Jan 15, 2011·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Timm BauerAnselm K Gitt
Jul 23, 2014·Pathology International·Yoshihiko IkedaHatsue Ishibashi-Ueda
Sep 10, 2013·Journal of cardiology·Cagatay ErtanBulent Ozin
Feb 4, 2016·Expert Review of Cardiovascular Therapy·Sara C Martinez, David R Holmes
May 31, 2014·Journal of Diabetes Science and Technology·Ehrin J ArmstrongJason H Rogers

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