Diffuse neonatal hemangiomatosis: an evidence-based review of case reports in the literature

Journal of the American Academy of Dermatology
Zoey R GlickBeth A Drolet

Abstract

The term "diffuse neonatal hemangiomatosis" has been used historically to describe multifocal vascular lesions affecting the skin and viscera in infants. We hypothesized that many cases reported as diffuse neonatal hemangiomatosis did not have infantile hemangiomas (IH), but represented more recently described neonatal vascular diseases. A literature search was performed using PubMed database (1950-2009) with the terms "neonatal hemangiomatosis," "benign hemangiomatosis," and "diffuse hemangiomatosis." A total of 180 articles were identified. Exclusion criteria included disease onset later than 3 years of age and absence of multifocal skin involvement. In all, 73 cases were selected and categorized into 3 groups: IH/probable IH; multifocal lymphangioendotheliomatosis with thrombocytopenia (MLT)/probable MLT; and multifocal vascular lesions, not otherwise specified. Of the 73 cases, 43 had IH/probable IH, 17 had MLT/probable MLT, and 13 had multifocal vascular lesions, not otherwise specified. The clinical outcomes of these groups differed in that two of 43 (5%) patients with IH died whereas 11 of 17 (65%) patients with MLT died (odds ratio 37.6, confidence interval 5.6-387.6, P value < .0001). This was a literature-based meta-a...Continue Reading

References

Feb 1, 1986·Pediatric Dermatology·L E GolitzO P O'Meara
Apr 1, 1997·The Journal of Pediatrics·O EnjolrasJ P Escande
Oct 23, 1997·Pediatric Dermatology·M Evole-BuselliG Sorni-Valls
Dec 12, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ingrid WittersJean Pierre Fryns
May 19, 2004·Archives of Dermatology·Denise W MetryIlona J Frieden
Jul 22, 2005·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Vinay PrasadHarry P W Kozakewich
Mar 15, 2006·Acta Obstetricia Et Gynecologica Scandinavica·Eleonora CvetanovskaRita Kahn
Dec 6, 2008·Pediatric Blood & Cancer·Mandi MaronnMichael Kelly
Dec 25, 2008·Virchows Archiv : an International Journal of Pathology·Elisabeth BruderHarry P W Kozakewich
Oct 28, 2009·Pediatrics·Denise MetryUNKNOWN PHACE Syndrome Research Conference

❮ Previous
Next ❯

Citations

Sep 24, 2013·Journal of Neurosurgery. Pediatrics·Christina HuangMark S Dias
Mar 19, 2014·Pediatric Clinics of North America·Katherine B Püttgen
Apr 6, 2013·Dermatologic Clinics·Kristen E Holland, Beth A Drolet
Nov 27, 2015·Pediatric Dermatology·Jorge Ocampo-GarzaJorge Ocampo-Candiani
Oct 31, 2016·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Eulalia Baselga TorresMaría Asunción Vicente Villa
Mar 19, 2014·Journal of the American Academy of Dermatology·Juliette MiquelAlain Dupuy
Jan 18, 2014·The Journal of Pediatrics·Tracy FunkAnna L Bruckner
Feb 10, 2016·Acta Paediatrica·Roie TalAvraham Lorber
Jun 11, 2016·Pediatric Dermatology·Agustina LanöelAndrea Bettina Cervini
Sep 8, 2016·Pediatric Dermatology·Antonia Reimer, Peter H Hoeger
Apr 27, 2017·Journal of Pharmacy Practice·Ashley B ClarkJennee Nickleson
Jan 22, 2018·Dermatology : International Journal for Clinical and Investigative Dermatology·Rivka FriedlandAlex Zvulunov
Aug 27, 2019·Pediatric Dermatology·Lander Peña MerinoMaria Rosario González-Hermosa
Sep 5, 2020·CVIR Endovascular·Craig R Gibson, Alex M Barnacle
Jul 22, 2020·Current Opinion in Pediatrics·Manuel Valdebran, Lara Wine Lee
Apr 22, 2020·Pathology International·Raffaele GaetaAlessandro Franchi
Dec 4, 2020·World Journal of Gastroenterology : WJG·Michael J Schmalz, Kadakkal Radhakrishnan
May 22, 2019·Journal of Gynecology Obstetrics and Human Reproduction·Sophie HamoudaFlorence Bretelle
May 28, 2021·QJM : Monthly Journal of the Association of Physicians·K O'DonovanT E McManus
Jul 11, 2021·AJNR. American Journal of Neuroradiology·T FeyginA N Pollock
Mar 18, 2015·Pediatrics·Rocío Porcel ChacónJuan Navarro Morón
Dec 26, 2012·Pediatrics·Tina S ChenSheila Fallon Friedlander

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aortic Coarctation

Aortic coarctation is a congenital condition characterized by narrowing of the aorta. Discover the latest research on this disease here.

Cavernous Hemangioma

Cavernous hemangioma is a blood vessel defect or benign tumor that leads to leakage of blood to the surrounding tissues. This can occur in several organs including the brain, which can lead to seizures. Discover the latest research on cavernous hemangiomas here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

Journal of the American Academy of Dermatology
J D GellerK Hashimoto
Journal de gynécologie, obstétrique et biologie de la reproduction
X CapelleJ-M Foidart
Journal of the American Academy of Dermatology
J K SternM Jarratt
The New England Journal of Medicine
Christine Léauté-LabrèzeAlain Taïeb
© 2022 Meta ULC. All rights reserved