Diffuse optical assessment of cerebral-autoregulation in older adults stratified by cerebrovascular risk.

Journal of Biophotonics
Ahmed A BahraniGuoqiang Yu

Abstract

Diagnosis of cerebrovascular disease (CVD) at early stages is essential for preventing sequential complications. CVD is often associated with abnormal cerebral microvasculature, which may impact cerebral-autoregulation (CA). A novel hybrid near-infrared diffuse optical instrument and a finger plethysmograph were used to simultaneously detect low-frequency oscillations (LFOs) of cerebral blood flow (CBF), oxy-hemoglobin concentration ([HbO2 ]), deoxy-hemoglobin concentration ([Hb]) and mean arterial pressure (MAP) in older adults before, during and after 70° head-up-tilting (HUT). The participants with valid data were divided based on Framingham risk score (FRS, 1-30 points) into low-risk (FRS ≤15, n = 13) and high-risk (FRS >15, n = 11) groups for developing CVD. The LFO gains were determined by transfer function analyses with MAP as the input, and CBF, [HbO2 ] and [Hb] as the outputs (CA ∝ 1/Gain). At resting-baseline, LFO gains in the high-risk group were relatively lower compared to the low-risk group. The lower baseline gains in the high-risk group may attribute to compensatory mechanisms to maintain stronger steady-state CAs. However, HUT resulted in smaller gain reductions in the high-risk group compared to the low-risk g...Continue Reading

References

Jan 1, 1991·The American Journal of Physiology·N H Holstein-RathlouD J Marsh
Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·R AaslidH Nornes
Sep 1, 1995·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·A J Catto, P J Grant
Jan 1, 1994·Stroke; a Journal of Cerebral Circulation·R B D'AgostinoW B Kannel
Jan 1, 1997·Ultrasound in Medicine & Biology·M MarinoniL Amaducci
Jan 4, 2001·Stroke; a Journal of Cerebral Circulation·C HajatC D Wolfe
Jun 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·M A MintunM E Raichle
Oct 3, 2002·Circulation·Rong ZhangBenjamin D Levine
Feb 13, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·B N MankovskyD Ziegler
Jul 12, 2003·Stroke; a Journal of Cerebral Circulation·Brian J CareyJohn F Potter
Nov 6, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Takuya HayashiHidehiro Iida
Feb 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·H S Markus
Jul 21, 2006·Microvascular Research·Per KvandalKnut Arvid Kirkebøen
Oct 3, 2006·Journal of the Neurological Sciences·Matthias ReinhardAndreas Hetzel
Oct 3, 2008·Neurosurgical Focus·Leonardo Rangel-CastillaClaudia S Robertson
Oct 7, 2008·Ultrasound in Medicine & Biology·Farzaneh A SorondLewis A Lipsitz
Nov 1, 2008·Journal of Applied Physiology·Jurgen A H R ClaassenRong Zhang
Jan 12, 2010·Behavioural Brain Research·Arenda H E A Van Beek, Jurgen A H R Claassen
Feb 26, 2010·Physiological Measurement·Brian L EdlowJohn A Detre
Sep 25, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Henrik W SchytzMessoud Ashina
Jan 1, 2006·Heart International·Riccardo RaddinoLivio Dei Cas
May 11, 2012·American Journal of Hypertension·J Dedrick Jordan, William J Powers
Jul 20, 2012·Continuum : Lifelong Learning in Neurology·Halinder S Mangat
Aug 18, 2012·European Journal of Clinical Investigation·Dorte PhillipMessoud Ashina
Jan 31, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zengyong LiLiqian Lu
Apr 16, 2013·Microvascular Research·Zengyong LiLiqian Lu
Nov 27, 2014·Biomedical Optics Express·Wesley B BakerA G Yodh
Jul 24, 2015·Biomedical Optics Express·Andrea FarinaAntonio Pifferi

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Citations

Jun 16, 2021·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tsubasa TsutsumiTakuji Torimura

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