Diffuse Optical Characterization of the Healthy Human Thyroid Tissue and Two Pathological Case Studies

PloS One
Claus LindnerTurgut Durduran

Abstract

The in vivo optical and hemodynamic properties of the healthy (n = 22) and pathological (n = 2) human thyroid tissue were measured non-invasively using a custom time-resolved spectroscopy (TRS) and diffuse correlation spectroscopy (DCS) system. Medical ultrasound was used to guide the placement of the hand-held hybrid optical probe. TRS measured the absorption and reduced scattering coefficients (μa, μs') at three wavelengths (690, 785 and 830 nm) to derive total hemoglobin concentration (THC) and oxygen saturation (StO2). DCS measured the microvascular blood flow index (BFI). Their dependencies on physiological and clinical parameters and positions along the thyroid were investigated and compared to the surrounding sternocleidomastoid muscle. The THC in the thyroid ranged from 131.9 μM to 144.8 μM, showing a 25-44% increase compared to the surrounding sternocleidomastoid muscle tissue. The blood flow was significantly higher in the thyroid (BFIthyroid = 16.0 × 10-9 cm2/s) compared to the muscle (BFImuscle = 7.8 × 10-9 cm2/s), while StO2 showed a small (StO2, muscle = 63.8% to StO2, thyroid = 68.4%), yet significant difference. Two case studies with thyroid nodules underwent the same measurement protocol prior to thyroidectomy....Continue Reading

References

Sep 1, 1987·The British Journal of Radiology·D R WhiteS M Hammond
Aug 28, 1995·Physical Review Letters·D A BoasA G Yodh
Sep 12, 2002·Physics in Medicine and Biology·T DurduranA G Yodh
Feb 14, 2003·Lancet·Steven I Sherman
Sep 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Subhadra SrinivasanKeith D Paulsen
Nov 4, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michael Jay PitmanStimson Pryor Schantz
Nov 11, 2005·Optics Letters·Turgut DurduranArjun G Yodh
Oct 7, 2006·Lasers in Medical Science·Kaustuv DasJ Christie-Brown
Jul 31, 2007·Journal of Magnetic Resonance Imaging : JMRI·Christina SchramlFritz Schick
Nov 21, 2007·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Silas ChikunguwoPhilip Schauer
Apr 12, 2008·Radiology·Won-Jin MoonUNKNOWN Thyroid Study Group, Korean Society of Neuro- and Head and Neck Radiology
Jul 25, 2008·Medical Physics·Bruce J TrombergAlbert E Cerussi
Dec 5, 2008·Medical Engineering & Physics·Sarah J Erickson, Anuradha Godavarty
Mar 5, 2009·Journal of Biomedical Optics·Wendy TanamaiBruce Tromberg
Oct 20, 2009·The Analyst·Caroline S B TeixeiraAirton A Martin
Oct 23, 2009·American Journal of Clinical Pathology·Edmund S CibasUNKNOWN NCI Thyroid FNA State of the Science Conference
Oct 29, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid CancerR Michael Tuttle
Nov 6, 2009·Thyroid : Official Journal of the American Thyroid Association·Edmund S Cibas, Syed Z Ali
Dec 17, 2009·Thyroid : Official Journal of the American Thyroid Association·Jennifer A Sipos
May 26, 2010·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Hossein GharibUNKNOWN AACE/AME/ETA Task Force on Thyroid Nodules
Jun 23, 2010·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S SancakR Paschke
Oct 19, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Rickson C MesquitaArjun G Yodh
Jan 20, 2012·Annals of Biomedical Engineering·Seth W PerryEdward B Brown
Dec 18, 2012·IEEE Journal of Selected Topics in Quantum Electronics : a Publication of the IEEE Lasers and Electro-optics Society·Regine Choe, Turgut Durduran
May 28, 2013·Oral Oncology·Bryan McIver
Jun 12, 2013·NeuroImage·Alessandro TorricelliLorenzo Spinelli
May 23, 2014·AJR. American Journal of Roentgenology·Vikram S DograNavalgund A Rao
Jun 6, 2014·Physiological Measurement·Parisa FarzamTurgut Durduran
Mar 4, 2015·Journal of Fluorescence·M P BrandaoL Bachmann
Jun 19, 2015·Journal of Biomedical Optics·Mariana BrandaoLuciano Bachmann
Jul 1, 2010·Reports on Progress in Physics·T DurduranA G Yodh

❮ Previous
Next ❯

Citations

Mar 17, 2017·Journal of Biomedical Optics·David DiazLeonid Zubkov
Jan 24, 2018·Biomedical Optics Express·Stanislaw WojtkiewiczHamid Dehghani
Jul 4, 2018·Scientific Reports·Sanathana Konugolu Venkata SekarAntonio Pifferi
Jun 1, 2019·Biomedical Optics Express·Stanislaw WojtkiewiczHamid Dehghani

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
biopsy
light scattering
diffuse correlation spectroscopy

Software Mentioned

R
nLME
SPCM
nortest

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.