Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation

Optics Letters
Turgut DurduranArjun G Yodh

Abstract

We combine diffuse optical and correlation spectroscopies to simultaneously measure the oxyhemoglobin and deoxyhemoglobin concentration and blood flow in an adult human brain during sensorimotor stimulation. The observations permit calculation of the relative cerebral metabolic rate of oxygen in the human brain, for the first time to our knowledge, by use of all-optical methods. The feasibility for noninvasive optical measurement of blood flow through the skull of an adult brain is thus demonstrated, and the clinical potential of this hybrid, all-optical noninvasive, methodology can now be explored.

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Citations

Jul 8, 2008·The Review of Scientific Instruments·D ResnatiA Geraci
Nov 13, 2007·Journal of Biomedical Optics·Elizabeth M C Hillman
Jan 1, 2008·Journal of Biomedical Optics·Martin WolfValentina Quaresima
Jul 2, 2009·Journal of Biomedical Optics·Chao ZhouArjun G Yodh
Jul 10, 2010·Journal of Biomedical Optics·Turgut DurduranDaniel J Licht
Feb 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Basavaraju G SanganahalliFahmeed Hyder
Oct 19, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Rickson C MesquitaArjun G Yodh
Feb 14, 2012·Cerebral Cortex·Pei-Yi LinMaria Angela Franceschini
Oct 19, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Hellmuth Obrig, Jens Steinbrink
Jan 21, 2014·Academic Radiology·David R BuschArjun G Yodh
Oct 25, 2006·The Journal of Thoracic and Cardiovascular Surgery·Jens SteinbrinkWolfgang M Kuebler
May 16, 2006·Photochemistry and Photobiology·Guoqiang YuArjun G Yodh
Nov 15, 2006·The European Journal of Neuroscience·Chris MartinJohn Mayhew
Jan 18, 2006·Journal of Theoretical Biology·Laszlo KocsisAndras Eke
Feb 2, 2013·NeuroImage·Nadege Roche-LabarbeMaria Angela Franceschini
Aug 26, 2014·Journal of Photochemistry and Photobiology. B, Biology·Jing DongKijoon Lee
Jul 31, 2012·Journal of Neuroscience Methods·S DubeauP Pouliot
Mar 24, 2015·Wilderness & Environmental Medicine·Matthew R SanbornDaniel S Martin
Nov 27, 2014·Biomedical Optics Express·Wesley B BakerA G Yodh
Mar 31, 2010·NeuroImage·Maria Angela FranceschiniDavid A Boas
Apr 6, 2013·NeuroImage·Hellmuth Obrig

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