Diffuse reflectance spectroscopy with a self-calibrating fiber optic probe.

Optics Letters
Bing YuNirmala Ramanujam

Abstract

Calibration of the diffuse reflectance spectrum for instrument response and time-dependent fluctuation as well as interdevice variations is complicated, time consuming, and potentially inaccurate. We describe a novel fiber optic probe with a real-time self-calibration capability that can be used for tissue optical spectroscopy. The probe was tested in a number of liquid phantoms over a relevant range of tissue optical properties. Absorption and scattering coefficients are extracted with an average absolute error and standard deviation of 6.9%+/-7.2% and 3.5%+/-1.5%, respectively.

References

Jun 30, 2001·Lasers in Surgery and Medicine·U UtzingerR Richards-Kortum
Nov 8, 2002·Journal of Biomedical Optics·Yvette N MirabalRebecca Richards-Kortum
Jan 25, 2003·Journal of Biomedical Optics·Urs Utzinger, Rebecca R Richards-Kortum
Jul 26, 2003·Journal of Biomedical Optics·Philippe ThuelerChristian Depeursinge
Apr 27, 2004·Cancer Biology & Therapy·Irving J Bigio, Stephen G Bown

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Citations

Feb 2, 2011·Journal of Biomedical Optics·Bing YuNirmala Ramanujam
Mar 10, 2009·Current Opinion in Biotechnology·J Quincy BrownNirmala Ramanujam
Aug 23, 2018·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Vivek K NagarajanBing Yu
Apr 2, 2014·Biomedical Optics Express·Bing YuDaron G Ferris
Apr 11, 2014·Optics Express·Lu WangDennis D Cox

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