Abstract
The diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) is an uncommon tumor making up about 2% of all papillary thyroid carcinomas. Previous studies have not comprehensively evaluated these tumors in a large series of patients. Twenty-two cases of DSV-PTC diagnosed between 1970 and 2000 were identified in the files of the AFIP. Histologic and immunohistochemical features were evaluated and patient follow-up was obtained. The tumors affected 14 females and 8 males, aged 6 to 49 yr (mean, 18 yr), with males presenting at a mean older age than females (24 vs 14 yr). Symptoms included an enlarging mass in the thyroid, present for a mean of 9.5 mo. While a dominant tumor was identified in a single lobe, bilateral disease was common (n = 16). The dominant mass ranged in size from 1.7 to 5.8 cm in diameter (mean, 3.8 cm). Histologically, all cases demonstrated a papillary carcinoma (conventional, solid, or follicular pattern) diffusely involving the gland. Extrathyroidal extension, lymphocytic thyroiditis, squamous metaplasia, increased fibrosis/sclerosis, and psammoma bodies were present to a variable degree. Both the papillary carcinoma and squamous metaplasia cells were strongly immunoreactive with CK19, thyroglobu...Continue Reading
Citations
Aug 22, 2013·Endocrine Pathology·Dong Yeob ShinEun Jig Lee
Apr 28, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sien-Yi SheuKurt Werner Schmid
Jun 5, 2007·Thyroid : Official Journal of the American Thyroid Association·Clara UgoliniAntonio Toniolo
Feb 12, 2011·Thyroid : Official Journal of the American Thyroid Association·Concetto RegalbutoVincenzo Pezzino
Oct 12, 2012·Thyroid : Official Journal of the American Thyroid Association·Chin-Sung KuoHong-Da Lin
Nov 9, 2011·Annals of Surgical Oncology·Hadiza S KazaureJulie A Sosa
Jul 16, 2010·Journal of Endocrinological Investigation·C RegalbutoV Pezzino
Oct 28, 2008·European Journal of Endocrinology·Geneviève SassolasFrançoise Borson-Chazot
Sep 13, 2014·International Journal of Endocrinology·Moira RagazziSimonetta Piana
Feb 10, 2009·World Journal of Surgery·Mitsuhiro FukushimaAkira Miyauchi
Nov 6, 2009·Thyroid : Official Journal of the American Thyroid Association·Ja Seung KooCheong Soo Park
May 16, 2013·Current Problems in Surgery·Judy JinChristopher R McHenry
Apr 18, 2009·Diagnostic Cytopathology·Massimo BongiovanniPatrick Meyer
Sep 22, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ja Seung KooSoon Won Hong
Sep 9, 2010·Head & Neck·Carl E SilverAlfio Ferlito
Mar 26, 2014·Cancer Cytopathology·Ricardo R LastraZubair W Baloch
Mar 7, 2015·World Journal of Surgery·Junko AkaishiKoichi Ito
Jul 3, 2015·Case Reports in Endocrinology·Jennifer WalshMatthew S Murphy
Jan 13, 2015·Critical Reviews in Oncology/hematology·Suja PillaiAlfred K-Y Lam
Nov 17, 2015·Histopathology·Ji Y JoungSun W Kim
Jun 22, 2016·Thyroid : Official Journal of the American Thyroid Association·Seo Ki KimJee Soo Kim
Dec 30, 2014·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Ji Hyun LeeEun Young Ko
Dec 15, 2017·Histopathology·Zubair W Baloch, Virginia A LiVolsi
May 16, 2018·Advances in Anatomic Pathology·Zhenying GuoRicardo V Lloyd
May 4, 2016·Current Opinion in Pediatrics·Andrew J Bauer, Gary L Francis
Jul 26, 2016·Molecular and Clinical Oncology·Nianyu XueFei Yu
Feb 6, 2010·Southern Medical Journal·Allen H LeungKamal K Khurana
Mar 7, 2014·Histopathology·Mary TonerConrad I Timon
Sep 16, 2017·The Journal of Clinical Endocrinology and Metabolism·David ViolaRossella Elisei
Dec 3, 2020·Endocrinology and Metabolism·Yanhua BaiChan Kwon Jung
Dec 14, 2016·Pathology·Shulin LowMotohiro Kobayashi