PMID: 6956914Aug 1, 1982Paper

Diffuse structural alterations in cell membranes of spontaneously hypertensive rats

Proceedings of the National Academy of Sciences of the United States of America
M A DevynckP Meyer

Abstract

Plasma membranes from heart, nerve endings, and liver were compared in 3-week-old male spontaneously hypertensive rats from the Okamoto substrain (SHR) and normotensive Wistar/Kyoto control rats (WKY) [systolic blood pressure 105 +/- 4 and 95 +/- 4 mm Hg, respectively (1 mm Hg = 133 Pa)] according to two criteria: calcium binding at physiological intracellular concentrations and polarization of an embedded fluorescent probe, 1,6-diphenyl-1,3,5-hexatriene. Whatever the tissue of origin, the density of high-affinity calcium binding sites was lower in SHR than in WKY plasma membranes, and the polarization of diphenylhexatriene fluorescence was constantly higher in SHR than in WKY membranes. These membrane abnormalities are similar to those previously described in the erythrocyte membrane from SHR. The presence of diffuse structural alterations in cellular membrane from young spontaneously hypertensive rats when blood pressure is still in the normotensive range suggests a genetic origin. Such inherited abnormalities may by themselves participate in the rise in blood pressure.

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Citations

Oct 16, 2003·Comptes rendus biologies·Jean-Luc SavelliJean-Pierre Poisson
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S KowarskiD Schachter
Dec 1, 1994·Journal of Autonomic Pharmacology·S A Doggrell, A J Surman
Jun 1, 1983·Pflügers Archiv : European journal of physiology·M De MendonçaP Meyer
Feb 15, 1988·Experientia·A RemmalP Marche
Jan 1, 1985·Clinical and Experimental Hypertension. Part A, Theory and Practice·S H BuckW Lovenberg
Apr 1, 1988·The American Journal of the Medical Sciences·P Meyer, P Marche
Jul 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M Narce, J P Poisson
Dec 1, 1986·Hypertension·J ZichaJ Jelínek
Nov 1, 1985·Hypertension·P B Furspan, D F Bohr
Jun 1, 1992·Hypertension·H YamakawaT Saruta
Dec 1, 1991·Hypertension·A F DominiczakD F Bohr
Nov 15, 2000·American Journal of Hypertension·A McLauren DorranceR Fraser
Jul 30, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J L SavelliJ-P Poisson

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