Diffusion and concentration of molecular probes in thermoresponsive poly(N-isopropylacrylamide) hydrogels: effect of the volume phase transition

Analytical Chemistry
Weimin ZhangMalgorzata Ciszkowska

Abstract

Poly(N-isopropylacrylamide), NIPA, thermoresponsive hydrogels with well-defined concentrations of an electroactive probe, 1,1'-ferrocenedimethanol, Fc(MeOH)2, were prepared. The discontinuous reversible volume phase transition of such gels occurs at 32 +/- 1 degrees C and results in a release of approximately 93% of the solution from the polymeric network. Transport of Fc(MeOH)2 in both swollen and collapsed gels was studied using steady-state voltammetry and chronoamperometry at platinum microelectrodes. The diffusion coefficient of Fc(MeOH)2 in collapsed gels was approximately 2 orders of magnitude smaller than that in swollen gels. UV/vis spectroscopic studies showed that for 3.0% NIPA gel, the concentration of Fc(MeOH)2 in the collapsed phase was approximately 6 times higher than that in released solution and 4.5 times higher than in the original swollen gel.

Citations

Sep 26, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Songmiao LiangLina Zhang
Oct 7, 2016·Chemical Society Reviews·Christopher D Jones, Jonathan W Steed
Oct 13, 2016·Physical Chemistry Chemical Physics : PCCP·Haidong LiNeso Sojic
Jan 23, 2003·Chemical Communications : Chem Comm·Peng WangMichael Grätzel
Apr 2, 2013·Journal of the American Chemical Society·Florent PinaudNeso Sojic
Jan 2, 2018·The Journal of Physical Chemistry Letters·Haidong LiNeso Sojic
Feb 1, 2007·The Journal of Physical Chemistry. B·Yimei YinKatsuyoshi Nishinari
Jul 21, 2006·The Journal of Physical Chemistry. B·Wojciech HykMalgorzata Ciszkowska

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