PMID: 12752524May 20, 2003Paper

Diffusion and short-term efficacy of botulinum toxin A after the addition of hyaluronidase and its possible application for the treatment of axillary hyperhidrosis

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Greg Goodman

Abstract

Botulinum toxin adequately treats hyperkinetic facial lines and hyperhidrosis. Higher doses of botulinum toxin appear to enhance efficacy and longevity possibly through greater evenness of diffusion; however, recurrent treatments with higher doses are expensive. To admix botulinum toxin with hyaluronidase and to test whether there is maintenance of efficacy, a spread of effect, and possibly a decrease in required dose compared with botulinum toxin. Six patients participated in a double-blinded side-to-side comparison pilot study with photographic analysis for frontalis overactivity and Minor's iodine and gravimetric testing for axillary hyperhidrosis. Initial efficacy of botulinum with admixed hyaluronic acid appeared maintained with possibly increased diffusion when hyaluronic acid is added. No difference was evident on short-term review of patients treated with 50 U of botulinum in one axilla compared with the contralateral side injected with 25 U with admixed hyaluronidase. There may be a role for hyaluronic acid in aiding diffusion and decreasing the required dose of botulinum toxin in hyperhidrosis axillaris.

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Citations

Jun 14, 2013·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Tomasz J Stefaniak, Monika Proczko
Jul 23, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ada R Trindade De AlmeidaAlastair Carruthers
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Dec 20, 2014·Clinical and Experimental Dermatology·A B Hussain, G M Kavanagh

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