Diffusion Coefficient-Formula Weight (D-FW) Analysis of (2)H Diffusion-Ordered NMR Spectroscopy (DOSY)

The Journal of Organic Chemistry
Jie GuangPaul G Williard

Abstract

We report extension of the D-FW analysis using referenced (2)H DOSY. This technique was developed in response to limitations due to peak overlay in (1)H DOSY spectra. We find a corresponding linear relationship (R(2) > 0.99) between log D and log FW as the basis of the D-FW analysis. The solution-state structure of THF solvated lithium diisopropyl amide (LDA) in hydrocarbon solvent was chosen to demonstrate the reliability of the methodology. We observe an equilibrium between monosolvated and disolvated dimeric LDA complexes at room temperature. Additionally we demonstrate the application of the (2)H D-FW analysis using a compound with an exchangeable proton that is readily labeled with (2)H. Hence, the (2)H DOSY D-FW analysis is shown to provide results consistent with the (1)H DOSY method, thereby greatly extending the applicability of the D-FW analysis.

References

Jul 18, 2001·Journal of the American Chemical Society·J L Rutherford, D B Collum
Feb 18, 2004·Journal of Environmental Quality·Dongqiang ZhuElizabeth R Carraway
Jul 21, 2006·The Journal of Physical Chemistry. B·Jaroslav Kríz, Jirí Dybal
Aug 4, 2006·The Journal of Physical Chemistry. B·Cristiano GiordaniMasaru Nakahara
Mar 28, 2007·Angewandte Chemie·David B CollumAntonio Ramirez
Jun 8, 2007·The Journal of Physical Chemistry. B·Greg MoakesJiri Janata
Feb 7, 2008·Organic Letters·Deyu LiPaul G Williard
May 8, 2008·The Journal of Organic Chemistry·Jia LiuPaul G Williard
Oct 7, 2008·Journal of Medicinal Chemistry·Jianxin GuoAlexandros Makriyannis
Mar 28, 2009·Journal of the American Chemical Society·Deyu LiPaul G Williard
Aug 4, 2010·The Journal of Organic Chemistry·Baptiste LecacheyJacques Maddaluno
Dec 15, 2010·The Journal of Organic Chemistry·Gerald KaganPaul G Williard
Apr 7, 2011·Journal of the American Chemical Society·Gabriella Barozzino ConsiglioHassan Oulyadi
Apr 14, 2011·Journal of the American Chemical Society·Gerald KaganPaul G Williard
Jun 8, 2011·Angewandte Chemie·Tanja TaticDietmar Stalke
Sep 29, 2011·Chemical Communications : Chem Comm·Ma Teresa MuñozTomás Cuenca
Jan 10, 2012·The Analyst·Marcus B FostonArthur Ragauskas
Sep 4, 2012·The Journal of Chemical Physics·Rémi BusselezBernhard Frick
Sep 11, 2012·The Journal of Physical Chemistry. B·Eduardo M ClopAna K Chattah
Jul 24, 2013·Journal of the American Chemical Society·Chicheung SuPaul G Williard
Aug 1, 2013·Chemical Communications : Chem Comm·Raúl García-Rodríguez, Haitao Liu
Aug 29, 2013·Journal of the American Chemical Society·Chicheung SuPaul G Williard
Oct 19, 2013·The Journal of Organic Chemistry·Chicheung SuPaul G Williard
Jan 24, 2014·Journal of the American Chemical Society·Chicheung SuPaul G Williard
Mar 1, 2014·Chemical Communications : Chem Comm·Ngon T TranAnnaliese K Franz
Mar 13, 2014·Chemical Communications : Chem Comm·G HamdounH Oulyadi
Jul 24, 2014·Journal of the American Chemical Society·Chicheung SuPaul G Williard
Mar 3, 2015·Organic Letters·Hariharaputhiran SubramanianMukund P Sibi

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Citations

Jun 1, 2017·The Journal of Organic Chemistry·Onkei TaiPaul G Williard
Dec 17, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Samantha A OrrStuart D Robertson
May 26, 2016·Chemistry : a European Journal·Roman Neufeld, Dietmar Stalke
Jun 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hawraz I M AminMaurizio Fagnoni
Jul 22, 2021·Physical Chemistry Chemical Physics : PCCP·Lingyu JiaXianglin Hou
May 31, 2017·Journal of the American Chemical Society·Russell F AlgeraDavid B Collum
Feb 27, 2018·Analytical Chemistry·Robert EvansGareth A Morris

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