Diffusion-Influenced Transport of Ions across a Transmembrane Channel with an Internal Binding Site.

The Journal of Physical Chemistry Letters
Huan-Xiang Zhou

Abstract

We develop a microscopic theory for ion transport across a transmembrane channel with an internal binding site. The ion flux is determined by the rate constants for binding to the internal site from the two sides of the membrane and the corresponding unbinding rate constants. The binding rate constants are formulated in terms of diffusion-influenced reactions. The theory allows a reconciliation of experimental data on the conductance of the influenza A M2 proton channel with the structure and dynamics of the protein.

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Citations

Oct 21, 2011·The Journal of Chemical Physics·Jorge L Barreda, Huan-Xiang Zhou
Aug 25, 2011·The Journal of Chemical Physics·Alexander M BerezhkovskiiHuan-Xiang Zhou
Jul 1, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ruibin LiangGregory A Voth
Apr 10, 2012·Current Opinion in Virology·Timothy A CrossHuan-Xiang Zhou
Jan 21, 2011·Current Opinion in Structural Biology·Jun WangWilliam F DeGrado
Aug 21, 2010·Trends in Biochemical Sciences·Timothy A CrossHuan-Xiang Zhou
Feb 8, 2013·Protein Science : a Publication of the Protein Society·Huan-Xiang Zhou, Timothy A Cross
Feb 19, 2013·Bulletin of the Korean Chemical Society·Attila Szabo, Huan-Xiang Zhou
May 15, 2020·Journal of the American Chemical Society·Patrik AspermairJohannes Bintinger

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