Diffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population

Translational Psychiatry
Y LiT Jiang

Abstract

Schizophrenia has increasingly been considered a neurodevelopmental disorder, and the advancement of neuroimaging techniques and associated computational methods has enabled quantitative re-examination of this important theory on the pathogenesis of the disease. Inspired by previous findings from neonatal brains, we proposed that an increase in diffusion magnetic resonance imaging (dMRI) mean diffusivity (MD) should be observed in the cerebral cortex of schizophrenia patients compared with healthy controls, corresponding to lower tissue complexity and potentially a failure to reach cortical maturation. We tested this hypothesis using dMRI data from a Chinese Han population comprising patients from four different hospital sites. Utilizing data-driven methods based on the state-of-the-art tensor-based registration algorithm, significantly increased MD measurements were consistently observed in the cortex of schizophrenia patients across all four sites, despite differences in psychopathology, exposure to antipsychotic medication and scanners used for image acquisition. Specifically, we found increased MD in the limbic system of the schizophrenic brain, mainly involving the bilateral insular and prefrontal cortices. In light of the...Continue Reading

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Citations

Jun 11, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sung Woo JooJungsun Lee
Sep 23, 2021·Journal of Magnetic Resonance Imaging : JMRI·Huawei ZhangQiyong Gong

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Software Mentioned

SPSS Statistics
VBA
IIT
Brain Extraction Tool
TK
SPSS
DTI
IIT Human Brain Template

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