Diffusion MRI in early cancer therapeutic response assessment

NMR in Biomedicine
C J GalbánB D Ross

Abstract

Imaging biomarkers for the predictive assessment of treatment response in patients with cancer earlier than standard tumor volumetric metrics would provide new opportunities to individualize therapy. Diffusion-weighted MRI (DW-MRI), highly sensitive to microenvironmental alterations at the cellular level, has been evaluated extensively as a technique for the generation of quantitative and early imaging biomarkers of therapeutic response and clinical outcome. First demonstrated in a rodent tumor model, subsequent studies have shown that DW-MRI can be applied to many different solid tumors for the detection of changes in cellularity as measured indirectly by an increase in the apparent diffusion coefficient (ADC) of water molecules within the lesion. The introduction of quantitative DW-MRI into the treatment management of patients with cancer may aid physicians to individualize therapy, thereby minimizing unnecessary systemic toxicity associated with ineffective therapies, saving valuable time, reducing patient care costs and ultimately improving clinical outcome. This review covers the theoretical basis behind the application of DW-MRI to monitor therapeutic response in cancer, the analytical techniques used and the results obta...Continue Reading

References

Aug 1, 1990·Statistics in Medicine·E A Gehan, M A Schneiderman
Mar 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K D MerboldtM Deimling
Sep 1, 1994·Radiology·R R EdelmanF Schmitt
Dec 16, 1998·Journal of Magnetic Resonance Imaging : JMRI·H J LaubachS Warach
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·A M ChinnaiyanA Rehemtulla
Mar 22, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P S ToftsJ M Pope
Jun 22, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H LyngE K Rofstad
Dec 21, 2000·Journal of the National Cancer Institute·T L ChenevertB D Ross
Jul 31, 2002·Lancet·Andrzej Dzik-JuraszSimon Doran
Feb 22, 2003·European Journal of Radiology·Roland Bammer
Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yael MardorThomas Tichler
Jun 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Alexander F DeVriesWerner Judmaier
Jul 24, 2003·Neuroreport·Yusuke OkadaAkira Matsui
Nov 25, 2003·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Christian KremserAlexander de Vries
Feb 10, 2004·European Radiology·Hildur EinarsdóttirHenrik C F Bauer
May 14, 2004·Neoplasia : an International Journal for Oncology Research·Yael MardorRaphael Pfeffer
May 22, 2004·Physics in Medicine and Biology·Ioannis DelakisJanet P De Wilde
Oct 29, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Daniel A HamstraAlnawaz Rehemtulla
Nov 25, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Douglas BallonAnn A Jakubowski
Dec 23, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dirk StrumbergSiegfried Seeber
Feb 22, 2005·Neoplasia : an International Journal for Oncology Research·Rebecca J TheilmannAlison Stopeck
Apr 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Bradford A MoffatBrian D Ross
Nov 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Daniel A HamstraBrian D Ross
Mar 29, 2006·Journal of Vascular and Interventional Radiology : JVIR·Ihab R KamelJean-Francois H Geschwind
May 3, 2006·Cancer Research·Kuei C LeeBrian D Ross
Jul 11, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C Carl Jaffe
Jul 27, 2006·Journal of Vascular and Interventional Radiology : JVIR·Jie DengAndrew C Larson
Aug 19, 2006·Magnetic Resonance Imaging·Martin D PicklesLindsay W Turnbull
Dec 7, 2006·Neuroimaging Clinics of North America·Thomas L ChenevertBrian D Ross
Feb 14, 2007·Journal of Vascular and Interventional Radiology : JVIR·Ihab R KamelJean-Francois H Geschwind
Mar 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kuei C LeeAlnawaz Rehemtulla
Mar 22, 2007·Physics in Medicine and Biology·Denis Le Bihan

❮ Previous
Next ❯

Citations

Jun 14, 2016·Neoplasia : an International Journal for Oncology Research·Xiaoyu JiangJohn C Gore
Aug 9, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xiaoyu JiangJunzhong Xu
Jul 16, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Natalie L VoetsPuneet Plaha
Mar 29, 2019·Diagnostics·Natasha Hemicke LangerBarbara Malene Fischer
Jul 18, 2019·Journal of Magnetic Resonance Imaging : JMRI·Thomas W BuusErik M Pedersen
Jul 4, 2019·Scientific Reports·Xiaoyu JiangJohn C Gore
Sep 26, 2020·Acta Radiologica Open·Mayra Evelia Jiménez de Los SantosIsabel Sollozo-Dupont
Mar 3, 2020·Frontiers in Medicine·Justine PerrinJacques Barbet
May 7, 2020·Radiation Oncology·Christopher KurzMarco Riboldi
Feb 8, 2019·NMR in Biomedicine·Daniel Topgaard
Jan 22, 2021·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Tavarekere N Nagaraja, Ian Y Lee
Jan 17, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniel E HagamanMarites P Melancon
Aug 22, 2020·The British Journal of Radiology·Nina TunariuDow-Mu Koh
May 1, 2021·Diagnostics·Rima HajjoAlexander Tropsha

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Magnetic Resonance Imaging : JMRI
Harriet C Thoeny, B D Ross
Journal of Magnetic Resonance Imaging : JMRI
Susanne BonekampIhab R Kamel
Ophthalmic Plastic and Reconstructive Surgery
Marta Calsina PratMichael Kazim
Current Pharmaceutical Biotechnology
Stefanie GalbánC J Galbán
© 2022 Meta ULC. All rights reserved