Diffusion tensor imaging and tract-based spatial statistics in Alzheimer's disease and mild cognitive impairment

Neurobiology of Aging
Yawu LiuHilkka Soininen

Abstract

We aimed to explore the changes in fractional anisotropy (FA) in subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD) by analyzing diffusion tensor imaging (DTI) data using the Tract-Based Spatial Statistics (TBSS). DTI data were collected from 17 AD patients, 27 MCI subjects and 19 healthy controls. Voxel-based analysis with TBSS was used to compare FA among the three groups. Additionally, guided by TBSS findings, a region of interest (ROI)-based analysis along the TBSS skeleton was performed on group-level and the accuracy of the method was assessed by the back-projection of ROIs to the native space FA. Neurofiber tracts with decreased FA included: the parahippocampal white matter, cingulum, uncinate fasciculus, inferior and superior longitudinal fasciculus, corpus callosum, fornix, tracts in brain stem, and cerebellar tracts. Quantitative ROI-analysis further demonstrated the significant decrease on FA values in AD patients relative to controls whereas FA values of MCI patients were found in between the controls and AD patients. We conclude that TBSS is a promising method in examining the degeneration of neurofiber tracts in MCI and AD patients.

References

Dec 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C Pierpaoli, P J Basser
Apr 6, 1999·Archives of Neurology·R C PetersenE Kokmen
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Dec 26, 2001·Archives of Neurology·R C PetersenB Winblad
Mar 22, 2002·NeuroImage·Christopher R GenoveseThomas Nichols
May 23, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·M BozzaliM Filippi
Dec 25, 2002·Neurobiology of Aging·Geraldo F BusattoCassio M Bottino
Dec 21, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·C PennanenH Soininen
Feb 1, 2005·Journal of Geriatric Psychiatry and Neurology·Steven J ChoiBarry Reisberg
Jul 12, 2005·Neurobiology of Aging·David MedinaGlenn T Stebbins
Mar 8, 2006·Psychiatry Research·Olivier NaggaraJean-François Meder
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Jun 7, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·S E RoseJ B Chalk
Dec 15, 2006·NeuroImage·Stefan J TeipelHarald Hampel
Aug 7, 2007·British Journal of Neurosurgery·V F J NewcombeD K Menon
Apr 17, 2008·Human Brain Mapping·Jessica S DamoiseauxSerge A R B Rombouts

❮ Previous
Next ❯

Citations

Jul 11, 2013·European Radiology·Sven HallerKarl-Olof Lovblad
Feb 15, 2014·Journal of Neuroradiology. Journal De Neuroradiologie·Hanjian DuShaoji Yuan
Mar 7, 2012·Journal of the International Neuropsychological Society : JINS·Irene B MeierAdam M Brickman
Jul 3, 2013·Journal of the International Neuropsychological Society : JINS·Nikki H StrickerElizabeth C Leritz
Jul 7, 2012·PloS One·Laurence O'DwyerHarald Hampel
May 6, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Meredith N BraskiePaul M Thompson
Sep 14, 2014·Seminars in Ultrasound, CT, and MR·Marion SmitsJanne M Papma
Apr 2, 2014·Molecular Neurobiology·Zhaomin WuYufeng Wang
Oct 22, 2011·AJNR. American Journal of Neuroradiology·T HattoriH Mizusawa
Nov 15, 2011·AJNR. American Journal of Neuroradiology·T HattoriH Mizusawa
Sep 15, 2012·AJNR. American Journal of Neuroradiology·S HallerP Giannakopoulos
Sep 6, 2012·Psychiatry Research·Thomas van BruggenKlaus H Fritzsche
Dec 24, 2015·Frontiers in Behavioral Neuroscience·Linda L ChaoThomas C Neylan
May 10, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jeffrey L Cummings
Apr 1, 2015·Brain Imaging and Behavior·Paulo César Gonçalves MarquesNuno Jorge Carvalho Sousa
Dec 10, 2015·Clinical Neurology and Neurosurgery·Daniel HořínekZsigmond Tamás Kincses
Aug 5, 2015·Brain Imaging and Behavior·R D PereaR A Honea
Jun 1, 2015·Neuroscience·S-H LeeUNKNOWN Alzheimer’s disease Neuroimaging Initiative (ADNI)
Nov 29, 2014·Frontiers in Aging Neuroscience·Kejal Kantarci
Oct 14, 2014·Frontiers in Aging Neuroscience·Kenichi Oishi, Constantine G Lyketsos
Aug 25, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Srikala BharathMathew Varghese
Mar 13, 2012·Neurobiology of Aging·Junming ShaoChristian Sorg
Nov 25, 2016·Human Brain Mapping·Yan JinUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 7, 2014·Journal of the Neurological Sciences·Wenjun LiJoseph S Goveas
Sep 25, 2015·American Journal of Alzheimer's Disease and Other Dementias·Stavros J BaloyannisVassiliki G Costa
Jan 10, 2017·NeuroImage. Clinical·Chantel D MayoUNKNOWN Alzheimer's Disease Neuroimaging Initiative

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.