Diffusion tensor imaging detects clinically important axonal damage after mild traumatic brain injury: a pilot study

Journal of Neurotrauma
Jeffrey J BazarianDerick Peterson

Abstract

The goal of the current investigation was to detect clinically important axonal damage in cerebral white matter after mild traumatic brain injury (TBI) using diffusion tensor imaging (DTI). To this end, we evaluated a prospective, pilot study of six subjects with isolated mild TBI and six matched orthopedic controls. All subjects underwent DTI scanning, post-concussive symptom (PCS) assessment, and neurobehavioral testing within 72 h of injury. Fractional anisotropy (FA) and trace values in white matter voxels of whole brain and five preselected regions of interest (ROI) were compared in mild TBI and control subjects using a quantile approach. In addition, whole brain images were analyzed using voxel-based morphometry. All subjects underwent quality of life and repeat PCS assessment at 1 month. Whole brain images revealed significantly lower 1(st) percentile trace values (mean 0.465 vs. 0.488, p = 0.049) among mild TBI subjects. These trace values correlated with PCS scores at both 72 h (r = -0.57, p = 0.05) and 1 month (r = -0.61, p = 0.04). Analysis of ROIs showed mild TBI subjects to have significantly lower mean trace in the left anterior internal capsule (0.536 vs. 0.574, p = 0.007) and higher maximum ROI-specific median F...Continue Reading

References

Apr 27, 1999·Lancet·U C WieshmannS D Shorvon
Mar 20, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·F J Rugg-GunnJ S Duncan
Mar 29, 2001·Journal of Magnetic Resonance Imaging : JMRI·Denis Le BihanH Chabriat
Jun 1, 2001·Neurosurgery·R E AndersonG Settergren
Nov 10, 2001·IEEE Transactions on Medical Imaging·Daniel C AlexanderJ C Gee
Feb 21, 2003·Journal of Neurosurgery·Mark R LovellFreddie H Fu
Jul 2, 2003·Current Sports Medicine Reports·Mark R Lovell
Jul 12, 2003·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Michael W CollinsJoseph Maroon
Dec 3, 2003·Radiology·Setsu WakanaSusumu Mori
Sep 4, 2004·Information Processing in Medical Imaging : Proceedings of the ... Conference·Geoff J M Parker, Daniel C Alexander
Apr 22, 2005·Brain Injury : [BI]·Jeffrey J BazarianJess Kraus
Sep 24, 2005·Journal of Neurosurgery·Matilde IngleseRobert I Grossman
Dec 20, 2005·Acta neurochirurgica·Andras Buki, John T Povlishock
Jan 7, 2006·Journal of Neuroscience Research·Laura A HarsanM Said Ghandour
Jan 27, 2006·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Jeffrey J BazarianLynn Cimpello

Citations

Jan 12, 2011·Archives of Neurology·Carlos Marquez de la PlataRamon Diaz-Arrastia
Apr 19, 2013·Acta Neuropathologica·John E GreerJohn T Povlishock
May 5, 2012·Brain Imaging and Behavior·Michael C StevensSuzanne T Witt
Apr 6, 2012·Brain Imaging and Behavior·Arnaud MesséHabib Benali
Jun 7, 2012·Brain Imaging and Behavior·Semyon SlobounovKai Zhang
Jun 4, 2010·Current Pain and Headache Reports·Tad D Seifert, Randolph W Evans
Mar 2, 2010·Journal of the International Neuropsychological Society : JINS·Elizabeth K GearyDeborah M Little
Nov 13, 2010·Journal of the International Neuropsychological Society : JINS·Carlos Marquez de la PlataRamon Diaz-Arrastia
Jan 31, 2013·Seminars in Neurology·Brian L Edlow, Ona Wu
Oct 10, 2008·Journal of Neurotrauma·Nicholas R GallowayAndré Obenaus
Jul 16, 2010·Journal of Neurotrauma·Maja StulemeijerGuillén Fernández
Jul 27, 2011·Journal of Neurotrauma·Jill V HunterBarbara A Holshouser
Jul 12, 2011·Journal of Neurotrauma·Kevin D BrowneDouglas H Smith
Oct 16, 2012·Journal of Neurotrauma·Cameron B JeterPramod K Dash
Jan 11, 2013·Journal of Neurotrauma·Michael J HylinPramod K Dash
Dec 21, 2012·Journal of Neurotrauma·Douglas H SmithJohn T Povlishock
Dec 14, 2011·Topics in Magnetic Resonance Imaging : TMRI·Elan J GrossmanRoland Bammer
Jul 17, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Yuta AokiHiroshi Suwa
Oct 12, 2010·Stroke; a Journal of Cerebral Circulation·William J Powers
Jun 19, 2009·BMC Medical Imaging·Harald SchraderDiana Obelieniene
Jan 28, 2010·Journal of Rehabilitation Research and Development·Robert W Van BovenMichael W Weiner
Nov 13, 2013·Annual Review of Psychology·Amanda R RabinowitzHarvey S Levin
Aug 28, 2013·Journal of Neurotrauma·Minna WäljasGrant L Iverson
Jan 25, 2014·Journal of Rehabilitation Research and Development·Preethi Thiagarajan, Kenneth J Ciuffreda
Nov 24, 2012·Radiology·Yongxia ZhouYulin Ge
Nov 15, 2013·Journal of Neurotrauma·Khader M HasanPonnada A Narayana
Jan 31, 2012·Experimental Neurology·Victoria E JohnsonDouglas H Smith
May 14, 2014·Brain : a Journal of Neurology·Tero IlvesmäkiJuha Ohman

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.