Diffusion tensor imaging indices of acute muscle damage are augmented after exercise in peripheral arterial disease.

European Journal of Applied Physiology
Jon StavresLawrence I Sinoway

Abstract

Although it is known that peripheral arterial disease (PAD) is associated with chronic myopathies, the acute muscular responses to exercise in this population are less clear. This study used diffusion tensor imaging (DTI) to compare acute exercise-related muscle damage between PAD patients and healthy controls. Eight PAD patients and seven healthy controls performed graded plantar flexion in the bore of a 3T MRI scanner. Exercise began at 2 kg and increased by 2 kg every 2 min until failure, or completion of 10 min of exercise. DTI images were acquired from the lower leg pre- and post-exercise, and were analyzed for mean diffusivity, fractional anisotropy (FA), and eigenvalues 1-3 (λ1-3) of the medial gastrocnemius (MG) and tibialis anterior (TA). Results indicated a significant leg by time interaction for mean diffusivity, explained by a significantly greater increase in diffusivity of the MG in the most affected legs of PAD patients (11.1 × 10-4 ± 0.5 × 10-4 mm2/s vs. 12.7 × 10-4 ± 1.2 × 10-4 mm2/s at pre and post, respectively, P = 0.02) compared to healthy control subjects (10.8 × 10-4 ± 0.3 × 10-4 mm2/s vs. 11.2 × 10-4 ± 0.5 × 10-4 mm2/s at pre and post, respectively, P = 1.0). No significant differences were observed for ...Continue Reading

References

Feb 1, 1990·Biophysical Journal·D L Morgan
Aug 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C H MeyerD G Nishimura
Jan 1, 1995·European Journal of Applied Physiology and Occupational Physiology·M GleesonH Griffiths
Mar 10, 2000·Journal of Science and Medicine in Sport·D DwyerS Weinstein
Nov 14, 2002·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Louise J BeatonStuart M Phillips
Jan 22, 2003·Scandinavian Journal of Medicine & Science in Sports·Jesper L Andersen
Oct 16, 2003·Journal of Vascular Surgery·Iraklis I PipinosHani N Sabbah
Jan 6, 2005·Medicine and Science in Sports and Exercise·David C NiemanVictor A Brown
Jul 8, 2005·Journal of Clinical Nursing·Amelia Williamson, Barbara Hoggart
Jul 11, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Anneriet M HeemskerkGustav J Strijkers
Sep 19, 2009·Annals of Biomedical Engineering·Dimitrios C KarampinosJohn G Georgiadis
Jul 20, 2011·Journal of Magnetic Resonance Imaging : JMRI·Osamu YanagisawaToru Fukubayashi
Dec 23, 2011·Journal of Biomedicine & Biotechnology·Alan B McMillanRichard M Lovering
May 31, 2013·Comprehensive Physiology·Tara L HaasRonald L Terjung
Aug 21, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Erin K EnglundFelix W Wehrli
Feb 25, 2014·European Journal of Applied Physiology·Trevor C ChenKazunori Nosaka
Apr 30, 2014·NMR in Biomedicine·Nathan D BryantBruce M Damon
Jul 30, 2015·Journal of Magnetic Resonance Imaging : JMRI·Jos OudemanMartijn Froeling
Sep 8, 2016·Biomedical Reports·Jinfeng LiLin Ma
Sep 21, 2016·Sports Medicine·Jamie DouglasMike McGuigan
Sep 30, 2016·Medicine and Science in Sports and Exercise·Daniel Ludovic BelavýDieter Felsenberg
Jan 1, 2017·Physiological Reports·Adam R JajtnerJeffrey R Stout
Jan 27, 2017·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Mar 16, 2017·International Angiology : a Journal of the International Union of Angiology·Brian Lindegaard PedersenBjørn Quistorff
Jun 26, 2017·Journal of Vascular Surgery·Molly N SchieberSara A Myers
Sep 1, 2017·Journal of the American Heart Association·Majd AlGhatrifLuigi Ferrucci
Nov 29, 2017·The Journal of Surgical Research·Ryan A BeckerIraklis I Pipinos
Jan 26, 2018·Journal of Cachexia, Sarcopenia and Muscle·Giovanna DistefanoPaul M Coen
May 31, 2018·Atherosclerosis·Jun Shu, Gaetano Santulli
Jun 30, 2018·Medicine and Science in Sports and Exercise·Adam R JajtnerJay R Hoffman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.