Diffusion tensor imaging of articular cartilage as a measure of tissue microstructure

Osteoarthritis and Cartilage
R MederJ M Pope

Abstract

To use diffusion tensor MR micro-imaging to observe differences in magnitude and anisotropy of water diffusion between 'healthy' cartilage and cartilage enzymatically degraded to simulate arthritic damage. Diffusion tensor images (156 x 156 microm in-plane resolution, 2mm slice thickness) of bovine cartilage were obtained at either 4.7 or 7.0 T using pulsed field gradient spin echo sequences. The parameters determined were: maximum and mean diffusivity, direction of the maximum diffusion eigenvector with respect to the normal to the articular surface and fractional anisotropy (FA) of diffusion. Both maximum and mean diffusion eigenvalues were found to decrease, respectively, from approximately 1.95 x 10(-9) and 1.80 x 10(-9) m2 s(-1) at the articular surface to approximately 1.08 x 10(-9) and 0.79 x 10(-9) m2 s(-1) in the deep zone. A systematic change was observed in the direction of the eigenvector corresponding to maximum diffusivity, reflecting the expected change in orientation of the collagen macrofibrillar bundles. Degradation with trypsin to remove proteoglycans resulted in a 10-15% increase in apparent diffusion coefficient of water in the cartilage, with no apparent change in FA. These methods have the potential to be...Continue Reading

References

Nov 10, 1995·Archives of Biochemistry and Biophysics·Y XiaL W Jelinski
Nov 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R M HenkelmanM J Bronskill
Mar 1, 1994·Journal of Magnetic Resonance. Series B·P J BasserD LeBihan
Jul 1, 1993·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D BursteinB D Foy
Dec 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C Pierpaoli, P J Basser
Jun 11, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y Xia
Mar 18, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R KnaussK Arnold
May 9, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M T NieminenJ S Jurvelin
Mar 29, 2001·Journal of Magnetic Resonance Imaging : JMRI·D Le BihanH Chabriat
Mar 26, 2003·Journal of Magnetic Resonance Imaging : JMRI·Vladimír MlynárikSiegfried Trattnig
May 27, 2003·Journal of Magnetic Resonance Imaging : JMRI·Chris A McGibbonWilliam E Palmer
Apr 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L FilidoroC Glaser

❮ Previous
Next ❯

Citations

Oct 26, 2010·European Biophysics Journal : EBJ·Konstantin I Momot
May 26, 2011·Biomedical Imaging and Intervention Journal·G Dougherty
Nov 23, 2011·Radiology·José G RayaChristian Glaser
Aug 13, 2014·The Indian Journal of Radiology & Imaging·Bhawan K Paunipagar, Dd Rasalkar
Dec 3, 2014·Magnetic Resonance Imaging Clinics of North America·Richard Kijowski, Rajeev Chaudhary
Feb 15, 2013·The British Journal of Radiology·D A BinksA Radjenovic
Sep 19, 2009·Journal of Magnetic Resonance·Ping-Chang LinRichard G Spencer
Jun 26, 2009·Magnetic Resonance Imaging·Takashi AzumaSadami Tsutsumi
Dec 10, 2008·Clinics in Sports Medicine·Hollis G PotterLe Roy Chong
Apr 25, 2008·European Journal of Radiology·Luis Martí-BonmatíAngel Alberich-Bayarri
Mar 18, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G SteidleF Schick
Jan 25, 2013·International Journal for Numerical Methods in Biomedical Engineering·D M PierceG A Holzapfel
Dec 17, 2009·NMR in Biomedicine·Konstantin I MomotR Mark Wellard
Apr 12, 2011·IEEE Transactions on Medical Imaging·Magnus B LilledahlCatharina de Lange Davies
Oct 4, 2014·Osteoarthritis and Cartilage·N SritanyaratanaR Kijowski
Apr 14, 2015·Journal of Magnetic Resonance Imaging : JMRI·José G Raya
Apr 19, 2015·BMC Musculoskeletal Disorders·Taku UkaiJoji Mochida
Jul 13, 2007·Osteoarthritis and Cartilage·S K de VisserJ M Pope
Apr 13, 2011·Journal of Biomechanics·Michael B AlbroGerard A Ateshian
Aug 23, 2012·Biochemical and Biophysical Research Communications·S GhazanfariC V C Bouten
Aug 24, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Franz MaierDavid M Pierce
Jul 28, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Uran FeriziJosé G Raya
Sep 24, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Qingen MengAlison Jones
Jul 24, 2015·Journal of Biomechanical Engineering·Kelsey L KleinhansAlicia R Jackson
Mar 13, 2010·Annals of Biomedical Engineering·David M PierceGerhard A Holzapfel
Sep 12, 2019·Biomechanics and Modeling in Mechanobiology·Mohsen MalekiSalvatore Federico
Jun 15, 2017·Annals of Biomedical Engineering·Janty S ShogaChristopher Price

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.