Diffusion tensor imaging of early changes in corpus callosum after acute cerebral hemisphere lesions in newborns.

Neuroradiology
Andrea RighiniFabio Triulzi

Abstract

The main purpose was to investigate any early diffusion tensor imaging (DTI) changes in corpus callosum (CC) associated with acute cerebral hemisphere lesions in term newborns. We retrospectively analysed 19 cases of term newborns acutely affected by focal or multi-focal lesions: hypoxic-ischemic encephalopathy, hypoglycaemic encephalopathy, focal ischemic stroke and deep medullary vein associated lesions. DTI was acquired at 1.5 Tesla with dedicated neonatal coil. DTI metrics (apparent diffusion coefficient (ADC), fractional anisotropy (FA), axial λ(∐) and radial λ(⟂) diffusivity) were measured in the hemisphere lesions and in the CC. The control group included seven normal newborns. The following significant differences were found between patients and normal controls in the CC: mean ADC was lower in patients (0.88 SD 0.23 versus 1.18 SD 0.07 μm(2)/s) and so was mean FA (0.50 SD 0.1 versus 0.67 SD 0.05) and mean λ(∐) value (1.61 SD 0.52 versus 2.36 SD 0.14 μm(2)/s). In CC the percentage of ADC always diminished independently of lesion age (with one exception), whereas in hemisphere lesions, it was negative in earlier lesions, but exceeded normal values in the older lesions. CC may undergo early DTI changes in newborns with acu...Continue Reading

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Citations

Sep 22, 2011·Pediatric Radiology·Monica EpelmanSusan I Blaser
Feb 15, 2013·Orphanet Journal of Rare Diseases·Valentina CittonPietro Maffei
May 25, 2012·AJR. American Journal of Roentgenology·James M ProvenzaleSteven Chen
Nov 2, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·L ChichaR Guzman
Oct 15, 2014·Nature Reviews. Neurology·Irene KnueselEric P Prinssen
Mar 23, 2013·AJNR. American Journal of Neuroradiology·A M HeemskerkJ Dudink
May 8, 2013·Journal of Magnetic Resonance Imaging : JMRI·Xiangshui MengXiangxing Ma
Jan 23, 2013·Developmental Medicine and Child Neurology·Niek E van der AaLinda S de Vries
Nov 12, 2016·Brain & Development·Monika Bekiesinska-FigatowskaHanna Bragoszewska
Jul 1, 2012·The Neuroradiology Journal·J M ProvenzaleS Chen
Aug 24, 2017·Developmental Medicine and Child Neurology·Monika Bekiesińska-Figatowska
Jan 11, 2017·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Yin Jie ChenSuyash Mohan
Jun 4, 2021·NeuroImage. Clinical·Bianca OlivieriPia Wintermark

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