Diffusion tensor imaging tractography parameters of limbic system bundles in temporal lobe epilepsy patients

Journal of Magnetic Resonance Imaging : JMRI
Despina LiacuGiovanni de Marco

Abstract

To investigate changes in diffusion tensor imaging (DTI) measures in limbic system white matter of patients with temporal lobe epilepsy (TLE) using diffusion tensor tractography. DTI metrics including fractional anisotropy (FA), λ1, λ2, λ3, and trace (Tr) coefficients were obtained from tractography for bilateral fornix, superior and inferior cingulum fibers in 18 patients and 10 healthy controls. Hippocampal signal-to-noise ratio (SNR) quantitative analysis was performed in order to confirm the magnetic resonance imaging (MRI) hippocampal lesion presence or absence in TLE patients. Nine patients presented unilateral hippocampal sclerosis (TLE+HS) and nine patients had no signal abnormalities on conventional MRI (TLE-HS). On the ipsilateral seizure side, all three investigated tracts showed significant DTI indices abnormalities in both patient groups when compared with controls, most marked on the inferior cingulum. Contralateral to the seizure side, the three tracts presented significant DTI parameters in only the TLE+HS group when compared with controls. The DTI abnormalities found in the TLE-HS group may suggest that in the inferior cingulum the structural integrity is more affected than in the fornix or superior cingulum wh...Continue Reading

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Citations

May 15, 2013·Neurochemistry International·Andre Obenaus
Dec 10, 2013·Imaging in Medicine·Negar MemarianRichard J Staba
Apr 25, 2015·Annals of Clinical and Translational Neurology·Linda DouwSteven M Stufflebeam
Jun 23, 2016·NeuroImage. Clinical·Mohammad-Reza Nazem-ZadehHamid Soltanian-Zadeh
Apr 4, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L E Wearick-SilvaM L Nunes
Nov 24, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Oguz BaranNecmettin Tanriover

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