Abstract
The possibility exists that the cell internum is far more highly organised right down to the molecular level than was hitherto appreciated, to the point where ideas of a relatively solid-state chemistry model have been entertained (Coulson, R.A., 1993. The flow theory of enzyme kinetics--a role of solid geometry in the control reaction velocity in live animals. Int. J. Biochem. 25, 1445-1474). This contrasts sharply with the traditional dogma that diffusion is the mechanism by which molecules interact within an aqueous solution of the cell internum, although it should have been clear from an early stage that diffusion could not play other than a very restricted role in metabolic regulation. When physicists began to question certain aspects of the fundamental Law of Heat Conductance formulated over 170 years ago by Fourier, Diffusion Theory was also implicated (Maddox, J., 1989. Heat conductance is a can of worms. Nature 338, 373), and application of Fick's Laws of Diffusion to living systems criticised (Agutter P.S., Malone, P.C., Wheatley, D.N., 1995. Intracellular transport mechanisms: a critique of diffusion theory. J. Theoret. Biol. 176, 261-272). While we have argued (Wheatley, D.N., Malone, P.C., 1993. Heat conductance, d...Continue Reading
References
Jan 1, 1977·Progress in Biophysics and Molecular Biology·G R Welch
Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·R A Coulson
Mar 1, 1989·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·D N WheatleyD W Gregory
Feb 19, 1988·Science·D Bray, J G White
Nov 16, 1987·FEBS Letters·M N BerryG R Welch
Nov 28, 1986·Science·D K Srivastava, S A Bernhard
Feb 1, 1986·Journal of Cellular Physiology·M J BorrelliW C Dewey
Jan 28, 1985·Life Sciences·D N Wheatley
Jan 31, 1967·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B Katz, R Miledi
Aug 13, 1968·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·M V Tracey
Sep 4, 1965·Nature·B Katz, R Miledi
Jul 1, 1984·The Journal of Cell Biology·A M Mastro, A D Keith
Jul 1, 1984·The Journal of Cell Biology·P L Paine
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A M MastroA D Keith
Jan 1, 1984·Cell and Tissue Research·R B HannaM V Bennett
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J W WojcieszynK A Jacobson
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E H McConkey
Jan 1, 1982·Cold Spring Harbor Symposia on Quantitative Biology·G Albrecht-Buehler
Apr 1, 1981·Experimental Cell Research·C NationsI L Cameron
Jul 27, 1995·Nature·D Bray
Feb 24, 1994·Nature·W Almers
Jan 1, 1994·Bio Systems·D N Wheatley, J S Clegg
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M K Bennett, R H Scheller
Jan 1, 1993·Biology of the Cell·D N Wheatley, P C Malone
Feb 1, 1994·Current Opinion in Cell Biology·K Luby-Phelps
Nov 5, 1993·Cell·T SöllnerJ E Rothman
Oct 1, 1993·The International Journal of Biochemistry·R A Coulson
Mar 1, 1997·Biology of the Cell·P S Agutter, D N Wheatley
Dec 1, 1958·Archives of Biochemistry and Biophysics·B D DAVIS
Citations
Jan 6, 2012·Journal of Molecular Neuroscience : MN·Morris H BaslowDavid N Guilfoyle
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·P W Hochachka
Oct 21, 2005·Theoretical Biology & Medical Modelling·Charles L Howe
Apr 29, 2009·International Journal of Molecular Sciences·Valdur SaksRita Guzun
Mar 28, 2009·International Journal of Molecular Sciences·Valdur SaksTheo Wallimann
May 17, 2014·Biology·Christopher B Scott
Feb 4, 2012·Theoretical Biology & Medical Modelling·Zhejun Gong, Zhefeng Gong
Dec 21, 2002·Synapse·Jean Vautrin, Jeffery L Barker
Jan 14, 2009·Synapse·Jean Vautrin
Nov 21, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Francesca BranzoliItamar Ronen
Jul 2, 2005·Biosensors & Bioelectronics·Shalini Prasad, Jorge Quijano
Aug 8, 2013·Critical Reviews in Biotechnology·Christina G Siontorou, Fragiskos A Batzias
Nov 16, 2012·Biochimie·M H Baslow, D N Guilfoyle
Mar 29, 2000·Biophysical Journal·R A de GraafK Nicolay
Nov 25, 1998·Biophysical Journal·P BognerA Miseta
Sep 21, 2010·Journal of the American Psychoanalytic Association·Ruth R Imber
Jul 21, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P W Hochachka
Jun 22, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Julien ValetteVincent Lebon
Sep 22, 2017·Sleep·Salome KurthMonique K LeBourgeois
Apr 26, 2001·NMR in Biomedicine·K NicolayM J Kruiskamp
May 21, 2003·The Journal of Experimental Biology·Denys N Wheatley