Diffusion theory, the cell and the synapse

Bio Systems
D N Wheatley

Abstract

The possibility exists that the cell internum is far more highly organised right down to the molecular level than was hitherto appreciated, to the point where ideas of a relatively solid-state chemistry model have been entertained (Coulson, R.A., 1993. The flow theory of enzyme kinetics--a role of solid geometry in the control reaction velocity in live animals. Int. J. Biochem. 25, 1445-1474). This contrasts sharply with the traditional dogma that diffusion is the mechanism by which molecules interact within an aqueous solution of the cell internum, although it should have been clear from an early stage that diffusion could not play other than a very restricted role in metabolic regulation. When physicists began to question certain aspects of the fundamental Law of Heat Conductance formulated over 170 years ago by Fourier, Diffusion Theory was also implicated (Maddox, J., 1989. Heat conductance is a can of worms. Nature 338, 373), and application of Fick's Laws of Diffusion to living systems criticised (Agutter P.S., Malone, P.C., Wheatley, D.N., 1995. Intracellular transport mechanisms: a critique of diffusion theory. J. Theoret. Biol. 176, 261-272). While we have argued (Wheatley, D.N., Malone, P.C., 1993. Heat conductance, d...Continue Reading

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Citations

Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·P W Hochachka
Oct 21, 2005·Theoretical Biology & Medical Modelling·Charles L Howe
Mar 28, 2009·International Journal of Molecular Sciences·Valdur SaksTheo Wallimann
Feb 4, 2012·Theoretical Biology & Medical Modelling·Zhejun Gong, Zhefeng Gong
Dec 21, 2002·Synapse·Jean Vautrin, Jeffery L Barker
Nov 21, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Francesca BranzoliItamar Ronen
Sep 21, 2010·Journal of the American Psychoanalytic Association·Ruth R Imber
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Jun 22, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Julien ValetteVincent Lebon
Apr 26, 2001·NMR in Biomedicine·K NicolayM J Kruiskamp

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