Diffusion-weighted image and fluid-attenuated inversion recovery image mismatch: unclear-onset versus clear-onset stroke

Stroke; a Journal of Cerebral Circulation
Bum Joon KimDong-Wha Kang

Abstract

Mismatch in lesion visibility between diffusion-weighted image and fluid-attenuated inversion recovery image (DWI-FLAIR mismatch) has been proposed as a biomarker for the estimation of ischemic lesion age. The actual onset in some patients with unclear-onset stroke (UnCOS) may be close to the first-found abnormal time. We hypothesized that patients with UnCOS within a particular time window might have a similar DWI-FLAIR mismatch profile with patients with clear-onset stroke (COS). Patients who underwent MRI within 6 hours from first-found abnormal time were recruited retrospectively. Clinical characteristics and the proportion of DWI-FLAIR and perfusion-weighted image-DWI mismatch in each time window were compared between UnCOS and COS. The final analysis included 259 patients (114 with UnCOS and 145 with COS). Patients with UnCOS were older and had more severe stroke at baseline. Risk factors, stroke subtypes, and perfusion-weighted image-DWI mismatch did not differ between the 2 groups. The proportion of patients with DWI-FLAIR mismatch in UnCOS did not differ from COS within 2 hours of first-found abnormal time (50.0% versus 51.5%; P=0.92), but it was significantly lower in UnCOS than in COS at 2 to 3 hours (16.1% versus 44...Continue Reading

References

Dec 14, 1995·The New England Journal of Medicine·UNKNOWN National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
Nov 5, 1999·Cerebrovascular Diseases·N M BornsteinA D Korczyn
Jul 14, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y LiuH J Aronen
Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·John N FinkGottfried Schlaug
Jun 7, 2003·Cerebrovascular Diseases·Joaquín SerenaJosé Castillo
Aug 4, 2007·Stroke; a Journal of Cerebral Circulation·Keith W MuirShelagh B Coutts
May 17, 2008·Cerebrovascular Diseases·A-Hyun ChoDong-Wha Kang
Nov 21, 2009·Stroke; a Journal of Cerebral Circulation·Nishant K MishraKennedy R Lees
Dec 26, 2009·Stroke; a Journal of Cerebral Circulation·Martin EbingerJochen B Fiebach
Feb 5, 2010·Cerebrovascular Diseases·Gisele S SilvaKaren L Furie
May 11, 2011·Neurology·J MackeyJ P Broderick
Nov 1, 2011·Journal of Neurology·Annerose ZieglerStefanie Leistner
Dec 3, 2011·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Luisa RoveriGiancarlo Comi
Feb 14, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Branko N HuisaUNKNOWN University of California, Los Angeles Stroke Investigators
Apr 19, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Dong-Wha KangJong S Kim
Oct 25, 2012·Stroke; a Journal of Cerebral Circulation·Dong-Wha KangJong S Kim

❮ Previous
Next ❯

Citations

Jul 24, 2014·Journal of Thrombosis and Thrombolysis·Yun Zhen HuJian Chen
Jun 30, 2015·International Journal of Stroke : Official Journal of the International Stroke Society·Eva Neumaier-ProbstMarc Fatar
Oct 21, 2014·Journal of Stroke·Bum Joon KimDong-Wha Kang
Apr 14, 2016·Journal of Cancer Research and Therapeutics·Xiang-Qin He, Li-Na Wei
Sep 4, 2015·Neurology. Clinical Practice·Harold P Adams
Aug 28, 2014·Frontiers in Neurology·Anke WoutersVincent Thijs
Apr 21, 2017·International Journal of Stroke : Official Journal of the International Stroke Society·Götz ThomallaChristian Gerloff
Jan 29, 2020·Stroke; a Journal of Cerebral Circulation·Hyunna LeeDong-Wha Kang
Jul 17, 2020·Journal of Neurology·Yu-Lei ZhangYun-Cheng Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.