Diffusion-Weighted imaging and diffusion tensor imaging detect delayed graft function and correlate with allograft fibrosis in patients early after kidney transplantation

Journal of Magnetic Resonance Imaging : JMRI
Katja HueperDagmar Hartung

Abstract

To combine diffusion-weighted imaging (DWI) and diffusion tensor imaging (DTI) for detection of allograft dysfunction in patients early after kidney transplantation and to correlate diffusion parameters with renal function and renal histology of allograft biopsies. Between day 4 and 11 after kidney transplantation 33 patients with initial graft function and 31 patients with delayed graft function (DGF) were examined with a 1.5T magnetic resonance imaging (MRI) scanner. DTI and DWI sequences were acquired and fractional anisotropy (FA), apparent diffusion coefficient (ADCmono), pure diffusion (ADCdiff ), and the perfusion fraction (Fp) were calculated. Kidney biopsies in 26 patients were analyzed for allograft pathology, ie, acute tubular injury, inflammation, edema, renal fibrosis, and rejection. Histological results were correlated with MRI parameters. In the renal medulla FA (0.25 ± 0.06 vs. 0.29 ± 0.06, P < 0.01) and ADCmono (1.73 ± 0.13*10(-3) vs. 1.93 ± 0.16*10(-3) mm(2) /s, P < 0.001) were significantly reduced in DGF patients compared with patients with initial function. For ADCdiff and Fp similar reductions were observed. FA and ADCmono significantly correlated with renal function (r = 0.53 and r = 0.57, P < 0.001) and ...Continue Reading

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Jul 4, 2001·Journal of Magnetic Resonance Imaging : JMRI·M RiesN Grenier
Feb 20, 2003·Abdominal Imaging·N GrenierC Moonen
Nov 16, 2004·Lancet·Norberto PericoGiuseppe Remuzzi
Jul 6, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Anke SchwarzHermann Haller
Oct 20, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Patric HagmannReto Meuli
Feb 26, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K SolezM Valente
Mar 15, 2008·AJNR. American Journal of Neuroradiology·P MukherjeeR G Henry
Sep 16, 2008·Investigative Radiology·Mike NotohamiprodjoHenrik J Michaely
Dec 24, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sri G YarlagaddaChirag R Parikh
Jul 8, 2009·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·D BlondinH-J Wittsack
Jun 29, 2010·European Journal of Radiology·Mike NotohamiprodjoSteven P Sourbron
Jul 29, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hans-Jörg WittsackDirk Blondin
Mar 26, 2011·Radiology·Harriet C Thoeny, Frederik De Keyzer
Jul 16, 2011·Journal of the American Society of Nephrology : JASN·Tsutomu InoueHiromichi Suzuki
Sep 21, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A SiedleckiD C Brennan
Nov 22, 2012·Radiology·Rotem S LanzmanHans-Jörg Wittsack
Dec 14, 2012·Kidney International·Kim Solez, Lorraine C Racusen
Jan 29, 2013·Journal of Magnetic Resonance Imaging : JMRI·Jeff L ZhangVivian S Lee
Feb 9, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Adnan Sharif, Richard Borrows
Jan 30, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M HaasUNKNOWN Banff meeting report writing committee
May 1, 2015·American Journal of Physiology. Renal Physiology·Katja HueperDagmar Hartung
Jun 4, 2015·Transplantation Proceedings·M Guedes-MarquesA Mota

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Citations

Oct 28, 2016·Journal of Magnetic Resonance Imaging : JMRI·Sophie van BaalenMartijn Froeling
Apr 5, 2017·European Radiology·Philipp SteigerHarriet C Thoeny
Sep 25, 2017·The British Journal of Radiology·Elizabeth HollisAyman El-Baz
Oct 5, 2017·Acta Radiologica·Emin DegerMutlu Cihangiroglu
Mar 9, 2018·European Radiology·Stan BenjamensRobert A Pol
Aug 14, 2018·Journal of Magnetic Resonance Imaging : JMRI·Jia-Ying ZhouSheng-Hong Ju
Aug 24, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nicholas M SelbySteven Sourbron
Aug 24, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anna CaroliJean-Paul Vallée
Sep 25, 2018·Acta Radiologica·Katarzyna SulkowskaMarek Golebiowski
Mar 17, 2017·Clinical Journal of the American Society of Nephrology : CJASN·General LeungDarren A Yuen
May 28, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Yuan Meng YuLong Jiang Zhang
Oct 18, 2016·Current Opinion in Nephrology and Hypertension·Huda MahmoudNicholas M Selby
Mar 12, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lena BerchtoldSophie de Seigneux
Jul 1, 2020·Journal of Magnetic Resonance Imaging : JMRI·Eyesha HashimAnish Kirpalani
Sep 25, 2020·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Arwa Ahmed Al-QahtaniAkbar Shoukat Ali
Mar 21, 2018·Abdominal Radiology·Alexandra LjimaniRotem S Lanzman
Apr 13, 2019·Scientific Reports·Hisham AbdeltawabAyman El-Baz
Jul 16, 2017·European Radiology·Matti PeperhoveKatja Hueper
Dec 25, 2019·Scientific Reports·Joāo Dos Santos PeriquitoAndreas Pohlmann
Feb 1, 2021·Medical Image Analysis·Israa AlnazerChristine Fernandez-Maloigne
Feb 23, 2021·Drug Discovery Today·Anjali SrivastavaShrikant R Mulay
Nov 3, 2020·Transplantation Direct·Andrea Beck-TöllyGeorg A Böhmig
Mar 16, 2021·American Journal of Physiology. Renal Physiology·Darya MorozovKevin M Bennett
Apr 30, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Thorsten DerlinKatja Hueper
Jul 3, 2021·Journal of Clinical Medicine·José María Mora-GutiérrezNuria Garcia-Fernandez
May 14, 2021·Transplantation·Turgay Saritas, Rafael Kramann

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