Diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) mapping as a quantitative imaging biomarker for prediction of immunohistochemical receptor status, proliferation rate, and molecular subtypes of breast cancer

Journal of Magnetic Resonance Imaging : JMRI
Joao V HorvatKatja Pinker

Abstract

Diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) mapping is one of the most useful additional MRI parameters to improve diagnostic accuracy and is now often used in a multiparameric imaging setting for breast tumor detection and characterization. To evaluate whether different ADC metrics can also be used for prediction of receptor status, proliferation rate, and molecular subtype in invasive breast cancer. Retrospective. In all, 107 patients with invasive breast cancer met the inclusion criteria (mean age 57 years, range 32-87) and underwent multiparametric breast MRI. 3 T, readout-segmented echo planar imaging (rsEPI) with IR fat suppression, dynamic contrast-enhanced (DCE) T1 -weighted imaging, T2 -weighted turbo-spin echo (TSE) with fatsat. Two readers independently drew a region of interest on ADC maps on the whole tumor (WTu), and on its darkest part (DpTu). Minimum, mean, and maximum ADC values of both WTu and DpTu were compared for receptor status, proliferation rate, and molecular subtypes. Wilcoxon rank sum, Mann-Whitney U-tests for associations between radiologic features and histopathology; histogram and q-q plots, Shapiro-Wilk's test to assess normality, concordance correlation coefficient ...Continue Reading

References

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Citations

Jul 14, 2019·Journal of Magnetic Resonance Imaging : JMRI·Lei ZhangShandong Wu
Sep 15, 2019·Journal of Magnetic Resonance Imaging : JMRI·Mami IimaKaori Togashi
Jun 17, 2020·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Mami Iima
Nov 19, 2021·Journal of Magnetic Resonance Imaging : JMRI·Han Sol KangRobert Grimm

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Methods Mentioned

BETA
chemical exchange saturation transfer imaging
biopsy

Software Mentioned

SAS
OsiriX

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