Diffusion-weighted imaging in identifying breast cancer pathological response to neoadjuvant chemotherapy: A meta-analysis

Oncotarget
Wei ChuXuequan Huang

Abstract

Diffusion-weighted imaging (DWI) is increasingly used to identify pathological complete responses (pCRs) to neoadjuvant chemotherapy (NAC) in breast cancer. The aim of the present study was to assess the utility of DWI using a pooled analysis. Literature databases were searched prior to July 2017. Fifteen studies with a total of 1181 patients were included. The data were extracted to perform pooled analysis, heterogeneity testing, threshold effect testing, sensitivity analysis, publication bias analysis and subgroup analyses. The methodological quality was moderate. Remarkable heterogeneity was detected, primarily due to a threshold effect. The pooled weighted values were a sensitivity of 0.88 (95% confidence interval (CI): 0.81, 0.92), a specificity of 0.79 (95% CI: 0.70, 0.86), a positive likelihood ratio of 4.1 (95% CI: 2.9, 5.9), a negative likelihood ratio of 0.16 (95% CI: 0.10, 0.24), and a diagnostic odds ratio of 26 (95% CI: 15, 46). The area under the receiver operator characteristic curve was 0.91 (95% CI: 0.88, 0.93). In the subgroup analysis, the pooled specificity of change in the apparent diffusion coefficient (ADC) subgroup was higher than that in the pre-treatment ADC subgroup (0.80 [95% CI: 0.71, 087] vs. 0.63 ...Continue Reading

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Citations

Sep 15, 2019·Journal of Magnetic Resonance Imaging : JMRI·Mami IimaKaori Togashi
Jan 27, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Panli LiGang Huang
Jun 2, 2020·Frontiers in Medicine·Apekshya ChhetriJoseph V Rispoli
Apr 1, 2020·Journal of Magnetic Resonance Imaging : JMRI·Beatriu ReigLinda Moy
Sep 5, 2018·Radiology·Savannah C PartridgeUNKNOWN ACRIN 6698 Trial Team and I-SPY 2 Trial Investigators
Jul 31, 2019·Radiology·Ritse M MannLinda Moy
Feb 13, 2021·Journal of Personalized Medicine·Ioana Boca BeneAnca I Ciurea

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