Diffusion-weighted imaging in quiescent Crohn's disease: correlation with inflammatory biomarkers and video capsule endoscopy

Clinical Radiology
Eyal KlangMarianne M Amitai

Abstract

To investigate the role of restricted diffusion in quiescent Crohn's disease (CD) patients and its association with inflammatory biomarkers and endoscopic disease. Fifty-two quiescent CD patients prospectively underwent magnetic resonance enterography (MRE) and video capsule endoscopy (VCE) and were tested for the inflammatory biomarkers, faecal calprotectin (FCP) and C-reactive protein (CRP). Restricted diffusion in the distal ileum was qualitatively (absence/presence) and quantitatively (apparent diffusion coefficient [ADC]) assessed by two readers. The VCE-based Lewis score was calculated for the distal ileum. Restricted diffusion sensitivity and specificity for VCE ulcerations were assessed for patients with elevated (>100 μg/g) or normal (<100 μg/g) FCP. Receiver operating characteristic (ROC) curve was used to assess the ability of ADC to identify patients with concurrent VCE ulceration and elevated FCP. The sensitivity and specificity of restricted diffusion for patients with VCE ulceration were higher in patients with elevated FCP (reader 1: 71.4%, 80%, reader 2: 76.2%, 100%, respectively) compared to patients with normal FCP (reader 1: 46.2%, 61.5%; reader 2: 15.4%, 76.9%, respectively). The ADC had a high diagnostic a...Continue Reading

Citations

Nov 29, 2017·Journal of Crohn's & Colitis·Eyal KlangUNKNOWN Israeli IBD research Nucleus [IIRN)
May 31, 2018·Current Opinion in Gastroenterology·Helena Tavares de SousaFernando Magro
Apr 25, 2018·Therapeutic Advances in Gastroenterology·Noa RozendornEyal Klang
Feb 23, 2018·Therapeutic Advances in Gastroenterology·Inês Pita, Fernando Magro
Jun 30, 2018·Journal of Computer Assisted Tomography·Ahmed Abd-El Khalek Abd-ALRazek, Dalia Monir Fahmy
Jun 9, 2018·World Journal of Gastroenterology : WJG·Nai-Yi ZhuFei Miao
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Christopher MaBrian Gordon Feagan
Apr 22, 2020·Radiologia brasileira·Bruno Cunha Fialho CantarelliGiuseppe D'Ippolito
May 30, 2019·Journal of Clinical Biochemistry and Nutrition·Takeru OkuhiraHiroshi Tamai

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