Diffusion-Weighted Imaging infarct volume and neurologic outcomes after ischemic stroke

Journal of Neuroradiology. Journal De Neuroradiologie
A AttyéJ-F Le Bas

Abstract

This study's purpose was to demonstrate a relationship between growth of stroke volume measured on Diffusion-Weighted MRI (DWI) at admission (baseline) and 24 hours later (follow-up) and functional outcome at 90 days evaluated by the modified Rankin Scale (mRS). DWI infarct volumes were calculated, using an Analyze Software. Clinical outcomes were assessed at 90 days by the mRS. Univariate regression analysis was performed to assess the relationship between changes in DWI lesion volume and mRS less or equal to 1. Sixty-nine cases had serial DWI scans with a measurable lesion at baseline and follow-up. The median baseline National Institutes of Health Stroke Scale (NIHSS) was 10, 5 and 7 at 24 hours. At 90 days, the proportion of patients with Rankin less or equal to 1 was 51.7%. The average baseline volume was 19.7 cm(3) and average follow-up volume was 46.1 cm(3). For each 10 cm(3) of growth in DWI infarct volume, the odds ratio for a mRS less or equal to 1 was 10,1 (IC 95%, 3-33.9). The results of this study provide evidence of a significant inverse relationship between infarct growth measured by DWI and good functional clinical outcome at 90 days.

References

Feb 5, 2000·Stroke; a Journal of Cerebral Circulation·K C JohnstonE C Haley
Dec 13, 2005·Stroke; a Journal of Cerebral Circulation·Jeffrey L Saver
Aug 24, 2010·Journal of Neuroradiology. Journal De Neuroradiologie·C RossoS Lehéricy
Jul 23, 2011·Stroke; a Journal of Cerebral Circulation·Hakan SarikayaRalf W Baumgartner

❮ Previous
Next ❯

Citations

Nov 19, 2013·Journal of Neuroradiology. Journal De Neuroradiologie·Wei-I LeeBernard Yan
Feb 11, 2014·Journal of Neuroradiology. Journal De Neuroradiologie·Matthias GawlitzaKarl Titus Hoffmann
Mar 13, 2014·Journal of Neuroradiology. Journal De Neuroradiologie·Edouard MartinonAdrien Chavent
Jun 3, 2015·Journal of Neuroradiology. Journal De Neuroradiologie·Naïla BoudiafAlexandre Krainik

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.