Diffusion weighted imaging of liver lesions suspect for metastases: Apparent diffusion coefficient (ADC) values and lesion contrast are independent from Gd-EOB-DTPA administration

European Journal of Radiology
Matthias BenndorfPascal A T Baltzer

Abstract

Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) enhanced liver MRI is widely used for detection and differentiation of focal liver lesions. Diffusion weighted imaging (DWI) including apparent diffusion coefficient (ADC) measurements is increasingly utilised as a fast and, with limitations, quantitative method for liver lesion detection and characterisation. Herein we investigate whether the administration of Gd-EOB-DTPA affects DWI. 31 consecutive patients referred to standardised liver MRI (1.5T, Gd-EOB-DTPA, 0.025mmol/kg) were retrospectively reviewed. All underwent a breathhold DWI sequence before and after contrast agent administration (EPI-DWI, TR/TE (effective): 2100/62ms, b-values: 0 and 800s/mm(2)). Patients with previously treated liver lesions were excluded. Signal intensity of lesion, parenchyma and noise on DWI images as well as the ADC value were measured after identification by two observers in consensus using manually placed regions of interest. The reference standard was imaging follow-up determined separately by two radiologists. Data analysis included signal-to-noise (SNR) ratio and contrast-to-noise ratio (CNR) calculations, comparisons were drawn by employing multiple Bonferroni cor...Continue Reading

References

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Jun 26, 2010·Journal of Magnetic Resonance Imaging : JMRI·Kazuhiro SaitoKoichi Tokuuye

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Citations

Nov 7, 2015·Clinical & Experimental Metastasis·Emeline J RibotSylvain Miraux
Dec 2, 2019·European Radiology·Pascal BaltzerUNKNOWN EUSOBI international Breast Diffusion-Weighted Imaging working group
Mar 5, 2016·Journal of Computer Assisted Tomography·Hui Xiong, Yuan-Lin Zeng

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