Diffusion-weighted imaging predicts upgrading of Gleason score in biopsy-proven low grade prostate cancers

BJU International
Sung Yoon ParkSung Joon Hong

Abstract

To analyse whether diffusion-weighted imaging (DWI) predicts Gleason score (GS) upgrading in biopsy-proven low grade prostate cancer (PCa). A total of 132 patients who had biopsy-proven low grade (GS < 7) PCa, 3T DWI results, and surgical confirmation were retrospectively included in the study. Clinical variables (prostate-specific antigen, greatest percentage of cancer in a biopsy core and percentage of positive cores) and DWI variables (minimum apparent diffusion coefficient [ADCmin ] and mean ADC [ADCmean ]) were evaluated. ADCmin was measured, by two independent, blinded readers, using a region of interest (ROI) of 5-10 mm(2) at the area of lowest ADC value within a cancer, while ADCmean was measured using an ROI covering more than half of a cancer. Logistic regression and receiver-operating characteristic curve analyses were performed. The rate of GS upgrading was 46.1% (61/132). In both univariate and multivariate analyses, ADCmin and ADCmean were persistently significant for predicting GS upgrading (P < 0.05), whereas clinical variables were not (P > 0.05). In both readers' results, the area under the curve (AUC) of ADCmin was significantly greater than that of ADCmean (reader 1: AUC 0.760 vs 0.711; P < 0.001; reader 2: ...Continue Reading

References

Apr 12, 2002·BJU International·L EgevadP Stattin
Feb 21, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Peter A Humphrey
Sep 18, 2007·The Journal of Urology·Ofer N GofritArieh L Shalhav
Jan 22, 2008·The Journal of Urology·Fei DongEric A Klein
Oct 22, 2008·Radiology·Makoto SasakiUNKNOWN Acute Stroke Imaging Standardization Group-Japan (ASIST-Japan) Investigators
Mar 20, 2010·Urologia Internationalis·Harri VisapääUlf-Håkan Stenman
May 17, 2011·Radiographics : a Review Publication of the Radiological Society of North America, Inc·David BonekampKatarzyna J Macura
Sep 21, 2011·Radiology·Caroline M A HoeksJurgen J Fütterer
Feb 11, 2012·European Radiology·Jelle O BarentszUNKNOWN European Society of Urogenital Radiology
May 25, 2012·AJR. American Journal of Roentgenology·Sadhna VermaMukesh Harisinghani
Sep 6, 2013·Diagnostic and Interventional Radiology : Official Journal of the Turkish Society of Radiology·Ali Sami KıvrakFatih Kara
Nov 12, 2013·European Urology·Axel HeidenreichUNKNOWN European Association of Urology
Jun 19, 2014·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Hasmet SariciMuzaffer Eroglu

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Citations

Aug 24, 2017·AJR. American Journal of Roentgenology·Chen-Jiang WuHai-Bin Shi
Jun 14, 2019·International Urology and Nephrology·Piotr ZapałaPiotr Radziszewski

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