Diffusion-weighted MR imaging of the normal fetal brain: marker of fetal brain maturation

Journal de radiologie
C CartryC Adamsbaum

Abstract

To determine the reliability and variations of apparent diffusion coefficient (ADC) values in normal fetuses. Materials and methods. Retrospective study (2007-2008) on 22 normal fetal MR examinations, performed between 30 and 34 of gestation, using a routine protocol (T1W and T2W images in 3 planes, b=1,000 diffusion-weighted imaging) without sedation. ADC values were measured by placing 3 adjacent regions of interest (ROI) including a centrally located ROI over the right frontal and occipital white matter (6 ROI). reproducibility of adjacent ADC values (intraclass correlation coefficient: ICC) and comparison between frontal and occipital ADC values (Wilcoxon). The mean ADC value was 1.78 mm(2)/s for the frontal white matter (+ or - 0.10) and 1.66 mm(2)/s for the occipital white matter (+ or - 0.12) with excellent reproducibility (ICC=0.91 in the frontal lobe) and good reproducibility for adjacent measurements (ICC=0.7). A linear inverse correlation existed between ADC values and gestational age in the occipital lobes, and a significant fronto-occipital gradient existed after 32 weeks of gestational age. ADC value measurements are reliable and inversely correlated with gestational age due to fetal brain maturation. The existenc...Continue Reading

Citations

Oct 6, 2016·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·O J ArthursM Alison
Jun 1, 2011·Topics in Magnetic Resonance Imaging : TMRI·Robert C WelshMoriah E Thomason
Aug 30, 2014·World Journal of Radiology·Anat Biegon, Chen Hoffmann
Jun 21, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M Sanz CortesM A Belfort
Sep 4, 2021·AJNR. American Journal of Neuroradiology·J-Y RenS-Z Dong

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